Application of the N-dibenzyl protective group in the preparation of β-lactam pseudopeptidesFrlan, Rok (Avtor) Hrast Rambaher, Martina (Avtor) Gobec, Stanislav (Avtor) β-lactamsdibenzylaminoMitsunobu reactionnocardicinpseudopeptidesDespite the great importance of β-lactam antibiotics, there is still a limited number of synthetic approaches for the formation of β-lactam containing dipeptides. In this study, we report upon the stereoselective preparation of β-lactam-containing pseudopeptides, where different reaction conditions and NH$_2$ protective groups were tested to obtain compounds that contain 3-amino-azetidin-2-one. We demonstrate that the protective group is essential for the outcome of the reaction. Successful implementation of dibenzyl-protected serine-containing dipeptides through the Mitsunobu reaction can provide the desired products at high yields and stereoselectivity.20192021-10-22 11:43:38Članek v reviji132354sl