Beyond α-GalCer : medicinal chemistry insights driving structural evolution of CD1d ligands

Paradiso, Emiliano (avtor), Jakopin, Žiga (avtor)

CD1d-restricted glycolipids have emerged as a cornerstone in the development of next-generation immunotherapies. This perspective provides a comprehensive update on structure–activity relationships, specifically examining how modifications of the prototypical CD1d ligand α-galactosylceramide (α-GalCer) to the galactosyl headgroup, phytosphingosine base, and fatty acyl chain dictate the modulation of invariant natural killer T (iNKT) cell responses. We explore the key pharmacophores and receptor interactions that polarize subsequent immune response toward either a pro-inflammatory Th1 or an anti-inflammatory Th2 phenotype. Building upon the structural evolution of sophisticated chemotypes, we evaluate the potential of these agonists in synergistic combinations with other adjuvants. Furthermore, we highlight the emerging transition toward fully synthetic self-adjuvanting vaccines, which ensure cellular colocalization and coordinated activation by covalently integrating antigens with glycolipid agonists. Collectively, these advancements underscore the transformative potential of tailored glycolipid design in engineering specific and durable immunity against cancer and infectious diseases.

• Jezik: Angleški jezik
• Ključne besede: cancer, ligands, lipids, peptides, proteins, vaccination
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: Str. 13988−14019
• Številčenje: Vol. 69, iss. 12
• PID: 20.500.12556/RUL-189704
• UDK: 615.4:54:616-006
• ISSN pri članku: 1520-4804
• DOI: 10.1021/acs.jmedchem.6c00783
• COBISS.SI-ID: 281708547
• Datum objave v RUL: 13.10.2026

Gradivo je del revije

• Naslov: Journal of medicinal chemistry
• Skrajšan naslov: J. med. chem.
• Založnik: American Chemical Society
• ISSN: 1520-4804
• COBISS.SI-ID: 512806681

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: medicinska kemija, beljakovine, farmacevtska kemija, ligandi, cepljenje, rak, medicina, peptidi, lipidi

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P1-0420
• Naslov: Napredna imunološka zdravila in celični pristopi v farmaciji

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: J3-4496
• Naslov: Adjuvansi naslednje generacije za mukozna cepiva