Giant cutaneous melanoma presenting with hemorrhagic complications

Lovšin, Klemen (avtor), Plesničar, Ana (avtor), Cencelj-Arnež, Romi (avtor), Matjašič, Alenka (avtor), Luzar, Boštjan (avtor)

Giant cutaneous melanoma is a rare presentation characterized by significant morbidity and mortality. We report the case of a 45-year-old male presenting with an acute life-threatening hemorrhage from a giant melanoma on his right thigh. The tumor, measuring 90 × 50 × 85 mm, was immediately excised under local anesthesia to achieve hemostasis. The patient exhibited acute anemia and required postoperative blood transfusion. Histopathological analysis confirmed superficial spreading melanoma with a Breslow thickness of 85.0 mm and extensive ulceration. Genetic testing identified critical mutations, including BRAFV600D and alterations involving the ARID2, CDKN2A/B, AKT3, PTEN, and HRAS genes. Remarkably, no metastatic disease was detected upon thorough diagnostic evaluation. The patient received adjuvant immunotherapy with programmed cell death-1 inhibitors. Six months after the procedure, he remains free of metastasis. This case underscores the urgent need for timely recognition and intervention in giant melanoma with acute complications. It also highlights the effectiveness of modern adjuvant therapies in improving prognosis.

• Jezik: Angleški jezik
• Ključne besede: dermatologic surgery, dermatopathology, melanoma, skin cancer
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.03 - Drugi znanstveni članki
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: Str. 129-132
• Številčenje: Vol. 35, iss. 2
• PID: 20.500.12556/RUL-188592
• UDK: 617
• ISSN pri članku: 1318-4458
• DOI: 10.15570/actaapa.2026.1
• COBISS.SI-ID: 283158531

Avtorske pravice

Na pristajalni strani revije: https://acta-apa.mf.uni-lj.si/submissions.php navedeno, da je članek objavljen z licenco CC BY 4.0: https://creativecommons.org/licenses/by/4.0/.

• Datum objave v RUL: 24.09.2026

Gradivo je del revije

• Naslov: Acta dermatovenerologica Alpina, Panonica et Adriatica
• Skrajšan naslov: Acta dermatovenerolog. Alp. Panon. Adriat.
• Založnik: Association of Slovenian Dermatovenerologists
• ISSN: 1318-4458
• COBISS.SI-ID: 31649024

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.