Junctional-fluctuation-mediated fluidization of multi-phase-field epithelial monolayers

Graham, James N. (avtor), Rozman, Jan (avtor)

We analyze a multi-phase-field model for an epithelial monolayer with pairwise adhesions between neighboring cells following an Ornstein-Uhlenbeck process, representing the stochastic turnover of junctional molecular motors. These fluctuations in junctional adhesion result in rearrangements in the tissue, fluidizing it and producing diffusive cell motion. Similar junctional fluctuations have proven a very useful tool in the vertex model literature, and we hope they will be equally helpful to the multi-phase-field model approach. Moreover, we observe that the cells' effective diffusion coefficient depends nonmonotonically on the persistence time of the fluctuations, confirming results previously observed in the vertex model.

• Jezik: Angleški jezik
• Ključne besede: biophysics, cell mechanics, epithelial tissues
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FMF - Fakulteta za matematiko in fiziko
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: Str. 024407-1-024407-6
• Številčenje: Vol. 114, iss. 2
• PID: 20.500.12556/RUL-185988
• UDK: 577.3
• ISSN pri članku: 2470-0045
• DOI: 10.1103/lbph-g5kd
• COBISS.SI-ID: 288748035
• Datum objave v RUL: 25.08.2026

Gradivo je del revije

• Naslov: Physical review
• Skrajšan naslov: Phys. rev., E
• Založnik: American Physical Society
• ISSN: 2470-0045
• COBISS.SI-ID: 2048366611

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: biofizika, celična mehanika, epitelijsko tkivo