Urinary extracellular vesicles : toward non-invasive biomarker discovery in kidney graft monitoring

Tanzi, Adele (avtor), Branda, Elena (avtor), Lenassi, Metka (avtor), Vadrucci, Eleonora M. (avtor), Arnol, Miha (avtor), Bussolati, Benedetta (avtor)

Urinary extracellular vesicles (uEVs) have emerged as a promising and versatile source of non-invasive biomarkers for kidney allograft monitoring. This review summarizes current evidence on uEV-derived biomarkers, including proteins, gene expression signatures, microRNAs, and extracellular vesicle-associated DNA, highlighting their potential role in detecting allograft rejection, calcineurin inhibitor nephrotoxicity, and progressive graft dysfunction. Urinary EVs reflect molecular processes occurring within the graft, including immune activation, metabolic dysregulation, and tissue remodelling. Consequently, the analysis of uEVs may offer real-time information on graft status through a readily accessible biological fluid, complementing conventional surveillance strategies and enabling earlier detection of allograft injury. For kidney transplant recipients. The effective uEV translation into clinical practice will require a collective efforts to standardized analytical workflows, validate findings in large prospective multicentric studies, and integrate uEV-based assays into precision medicine approaches.

• Jezik: Angleški jezik
• Ključne besede: biomarkers, exosomes, kidney transplanation, rejection, urinary extracellular vesicles
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 11 str.
• Številčenje: Vol. 40, iss. 4, art. 101046
• PID: 20.500.12556/RUL-185791
• UDK: 616.6
• ISSN pri članku: 0955-470X
• DOI: 10.1016/j.trre.2026.101046
• COBISS.SI-ID: 287709955
• Datum objave v RUL: 20.08.2026

Gradivo je del revije

• Naslov: Transplantation reviews
• Skrajšan naslov: Transplant. rev.
• Založnik: Elsevier
• ISSN: 0955-470X
• COBISS.SI-ID: 512448537

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: biološki označevalci, eksosomi, presaditev ledvice, zavrnitev, urinski zunajcelični vezikli