Risk factors for venous thromboembolism in Slovenian children and adolescents : a single center experience

Leban, Mineja (avtor), Kavčič, Marko (avtor), Peterlin, Jakob (avtor), Jazbec, Janez (avtor), Faganel Kotnik, Barbara (avtor)

Venous thromboembolism (VTE) are rare but potentially life-threatening conditions in children, usually associated with underlying medical conditions. Some children with diagnosed VTE have genetic risk factors for the development of VTE, as well as for recurrent complications. This study reports risk factors for developing VTE in a homogeneous population of children and adolescents. A total of 155 children and adolescents, aged 0–21 years, who were diagnosed with VTE at the University Children's Hospital, UMC Ljubljana, between July 2006 and October 2021, were included. The median age at the time of the VTE diagnosis was 12.0 years (interquartile range: 1–7 years). Associated medical conditions were present in 75.5% of patients, and thrombophilia was diagnosed in 43.2% of patients. Oncological disease accounted for 27.7% of cases, while infections were found to be the most significant acquired risk factor (17.4%), followed by the presence of a central venous catheter (15.5%). Genetic thrombophilia markers were identified in 27.1% of patients, with the highest frequency in adolescents (62.5%). Factor V (FV) Leiden heterozygote was the most common marker (9.6% of patients), followed by elevated factor VIII (FVIII) activity (5.8%) and elevated Lp(a) levels (5.2%). Combined thrombophilia markers were found in 52.2% of patients. In addition to inherited thrombophilia, 83.3% of patients had acquired risk factors. Compared to previously reported prevalence, a lower occurrence of FV Leiden heterozygote, elevated Lp(a) levels, elevated FVIII activity and antiphospholipid syndrome was observed in our population.

• Jezik: Angleški jezik
• Ključne besede: acquired risk factors, genetic thrombophilia markers, inherited thrombophilia, pediatrics, venous thromboembolism
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 7 str.
• Številčenje: Vol. 13, art. 1729489
• PID: 20.500.12556/RUL-185465
• UDK: 616-053.2
• ISSN pri članku: 2296-2360
• DOI: 10.3389/fped.2025.1729489
• COBISS.SI-ID: 267918595
• Datum objave v RUL: 06.08.2026

Gradivo je del revije

• Naslov: Frontiers in pediatrics
• Skrajšan naslov: Front. pediatr.
• Založnik: Frontiers Media
• ISSN: 2296-2360
• COBISS.SI-ID: 523096601

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: pridobljeni dejavniki tveganja, genetski markerji trombofilije, dedna trombofilija, pediatrija, venska tromboembolija