Quality of life in Slovenian patients with skull base tumours : cross-cultural adaptation and validation of a Slovenian skull base inventory

Vozel, Domen (avtor), Urbančič, Jure (avtor), Battelino, Saba (avtor), Božanić Urbančič, Nina (avtor), Steiner, Nejc (avtor), Felbabić, Tomislav (avtor), Bošnjak, Roman (avtor)

Background: Skull base tumours frequently manifest as severe physical morbidity and quality of life (QoL) impairment. The disease-related QoL measurement can be performed with disease specific questionnaires, e.g. Skull base inventory (SBI). Patients and methods: The study consisted of two parts: (1) cross-cultural adaptation and psychometric testing of the Slovenian SBI (SBI-SLO) and (2) QoL assessment in skull base tumours. Two groups completed the SBI-SLO: 1.) adult patients without prior treatment of anterior, anterolateral and/or central skull base and 2.) healthy controls. Patients with skull-base tumours were further analysed for difference in SBI-SLO total score and domain scores between 1.) benign and malignant tumours and 2.) pituitary macroadenomas and other benign tumours. Results: 59 patients (46% male, 54% female, median age 57.7 years) and 47 subjects from control group (49% male, 51% female, median age 42,2 years) completed SBI-SLO, which demonstrated an excellent level of internal consistency (Cronbach's alpha = 0.924) and excellent test-retest reliability (intraclass correlation coefficient [ICCA] = 0.952). The discriminant validity was confirmed (p = 0.000). SBI-SLO total score, emotional, other and family domain scores were lower in malignant than in benign tumours (p = 0.031, p = 0.038, p = 0.008, and p = 0.046, respectively). Macroadenoma and other benign tumours differed only in neurological domain score (p < 0.05). Conclusions: A skull base tumour, especially malignant, can exert a substantial detrimental effect on a patient's quality of life. The SBI is a key tool for assessing QoL, also available in Slovenian.

• Jezik: Angleški jezik
• Ključne besede: quality of life, skull base, neoplasms, meningioma, carcinoma
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: Str. 106-113
• Številčenje: Vol. 60, iss. 1
• PID: 20.500.12556/RUL-185449
• UDK: 616-006
• ISSN pri članku: 1581-3207
• DOI: 10.2478/raon-2026-0007
• COBISS.SI-ID: 266450435
• Datum objave v RUL: 05.08.2026

Gradivo je del revije

• Naslov: Radiology and oncology
• Založnik: Association of Radiology and Oncology
• ISSN: 1581-3207
• COBISS.SI-ID: 784507

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: kakovost življenja, lobanja, novotvorbe, meningiom, karcinom