Inflammatory biomarkers as predictors of prognosis in patients after transcatheter aortic valve implantation

Vitez, Luka (avtor), Mihailović, Peter Marko (avtor), Božič Mijovski, Mojca (avtor), Jug, Borut (avtor), Bunc, Matjaž (avtor)

Background: The expanding role of transcatheter aortic valve implantation (TAVI) highlights the need to identify factors influencing long-term outcomes. Systemic inflammatory response syndrome (SIRS) is a frequent post-procedural event that may adversely affect prognosis. Measurement of inflammatory biomarkers may improve the understanding of underlying mechanisms and refine patient risk stratification. Methods: This single-center, prospective cohort study, enrolled 62 consecutive patients undergoing TAVI, who were followed for up to 5 years. Blood samples were collected before TAVI, at 24 h and 3–6 months post-procedure. Changes in biomarker levels, predictors of SIRS, and inflammatory predictors of long-term outcomes were analyzed. Results: SIRS developed in 45% of patients. Significant temporal changes were observed in hs-CRP, TNF-α, sST2/IL-33, IL-10, and IL-2 levels, irrespective of baseline or procedural characteristics. The development of SIRS was associated with a higher risk of all-cause mortality or unplanned hospitalization at 5 years (HR 3.07, 95% CI 1.57–6.00; p = 0.001). Baseline hs-CRP (HR 1.21, 95% CI 1.09-1.35; p < 0.001) and IFN-γ (HR 1.22; 95% CI 1.09–1.36; p < 0.001) levels were predictive of adverse outcomes. In multivariable Cox analysis, these associations remained, though findings should be interpreted cautiously given the limited sample size. Conclusions: SIRS is a common post-TAVI phenomenon and may be linked to long-term outcomes. Elevated pre-procedural hs-CRP and IFN-γ levels were associated with higher risk for adverse events, suggesting they may serve as exploratory biomarkers for risk stratification in this population.

• Jezik: Angleški jezik
• Ključne besede: systemic inflammatory response syndrome, SIRS, transcatheter aortic valve implantation, high sensitivity CRP, hs-CRP, interferon gamma, IFN-γ, inflammatory biomarkers
• Vrsta gradiva: Izvleček, povzetek
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 11 str.
• Številčenje: Vol. 12, art. 1722293
• PID: 20.500.12556/RUL-185264
• UDK: 616.1
• ISSN pri članku: 2297-055X
• DOI: 10.3389/fcvm.2025.1722293
• COBISS.SI-ID: 266429443
• Datum objave v RUL: 30.07.2026

Gradivo je del revije

• Naslov: Frontiers in cardiovascular medicine
• Skrajšan naslov: Front. cardiovasc. med.
• Založnik: Frontiers Media
• ISSN: 2297-055X
• COBISS.SI-ID: 523093273

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Projekti

• Financer: University Medical Centre of Ljubljana
• Številka projekta: 20230198