Anion coordination chemistry of benzoates with cationic biguanide-cobalt(III) : from binding studies to biological evaluation

Kumar, Bhupesh (avtor), Bala, Ritu (avtor), Prakash, Vinit (avtor), Verma, Jaya (avtor), Kaur, Simranjeet (avtor), Kaur, Simrandeep (avtor), Golobič, Amalija (avtor)

An anion-templated supramolecular strategy based on anion coordination-driven assemblies (ACDA) has been developed using a biguanide-cobalt(iii) complex as a functional building unit. In this approach, benzoate anions (ABA: p-aminobenzoate, NBA: p-nitrobenzoate, MBA: p-methylbenzoate and MEBA: p-methoxybenzoate) act as directing agents, promoting self-assembly with complex cation [Co(Hbig)$_3$]$^{3+}$ (Hbig: biguanide) via H-bonding and π–π stacking between adjacent para-substituted benzoates. The SCXRD studies also elucidate that benzoates exhibit varying numbers (up to 7) of H-bonding interactions with the complex cation as well as with lattice water. These interactions collectively facilitate the construction of ACDA and contribute to the overall stability of the supramolecular architecture. These architectures were also characterized by using spectroscopic techniques (UV-visible, FTIR and NMR), DLS and TGA. Anion coordination studies were performed to measure the binding affinities of benzoate anions towards the complex cation, signifying strong and selective anion coordination of NBA. Additionally, the ACDA were evaluated for biological activity (anticancer and antimicrobial), revealing promising potential as compared to their respective standard drugs.

• Jezik: Angleški jezik
• Ključne besede: para-substituted benzoates, biguanide-cobalt(III), crystal structure, anion-templated supramolecular strategy, anticancer and antimicrobial activity
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 15 str.
• Številčenje: Vol. , iss.
• PID: 20.500.12556/RUL-184583
• UDK: 546.733.022:615
• ISSN pri članku: 2046-2069
• DOI: 10.1039/d6ra02210c
• COBISS.SI-ID: 284301059
• Datum objave v RUL: 10.07.2026

Gradivo je del revije

• Naslov: RSC advances
• Založnik: RSC Publishing
• ISSN: 2046-2069
• COBISS.SI-ID: 2513252

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: para-substituirani benzoati, bigvanid-kobalt(III), kristalna struktura, supramolekularna strategija z anionskim usmerjanjem, protirakavo in protimikrobno delovanje

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P1-0175-2018
• Naslov: Napredna anorganska kemija

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: I0-0022-2022
• Naslov: Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)