Clinical data on symptomatic cutaneous reinfections due to Borrelia burgdorferi sensu lato in Slovenia

Strle, Franc (avtor), Ogrinc, Katarina (avtor), Maraspin-Čarman, Vera (avtor), Lotrič-Furlan, Stanka (avtor), Rojko, Tereza (avtor), Ružić-Sabljić, Eva (avtor), Kastrin, Andrej (avtor), Strle, Klemen (avtor), Wormser, Gary P. (avtor), Bogovič, Petra (avtor)

Background: Symptomatic reinfections with Borrelia burgdorferi sensu lato occur, but their clinical and microbiologic characteristics are insufficiently defined. It, therefore, remains unclear whether having had a primary infection influences the presentation or course of reinfection. Methods: We compared the clinical and microbiologic findings in patients with primary infection versus reinfection, with each episode presenting with erythema migrans (EM). The analysis included a cohort of patients diagnosed with EM between 1990 and 2014 at an outpatient clinic in Slovenia. Results: A total of 11,169 patients with EM were included, comprising 635 reinfections and 10,534 primary infections. Patients with reinfection were older (56 vs 48 years; p < 0.001), less frequently had multiple EM lesions (4.4% vs 7.3%; p = 0.022), and less often reported local symptoms at the EM site (42.5% vs 53.6%; p < 0.001). Reinfected patients were less often Borrelia IgM seropositive (35.0% vs 43.6%; p = 0.028) and more often IgG seropositive (63.0% vs 52.8%; p = 0.011). The rate of Borrelia isolation from EM skin lesions, however, was similar in both groups (53%). Reinfections were more frequent in immunocompromised than in immunocompetent patients (6.8% vs 2.4%; p < 0.001). Conclusions: Compared with primary infection, EM due to reinfection shows distinct clinical and serologic features and is less often disseminated. The increased frequency of reinfection among immunocompromised patients supports a role of host immunity in protection against Borrelia reinfection.

• Jezik: Angleški jezik
• Ključne besede: Lyme borreliosis , erythema migrans, Borrelia burgdorferi sensu lato, reinfection, cohort study
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: Str. 1347–1358
• Številčenje: Vol. 54, iss. 3
• PID: 20.500.12556/RUL-184253
• UDK: 616.9
• ISSN pri članku: 1439-0973
• DOI: 10.1007/s15010-026-02751-9
• COBISS.SI-ID: 269696771
• Datum objave v RUL: 02.07.2026

Gradivo je del revije

• Naslov: Infection
• Skrajšan naslov: Infection
• Založnik: Springer Nature
• ISSN: 1439-0973
• COBISS.SI-ID: 513677337

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: Lymska borelioza, erythema migrans, Borrelia burgdorferi sensu lato, reinfekcije, kohortna raziskava