Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk : a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Harewood, Rhea (avtor), Adamski, Jerzy (avtor)

Background: Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain. Methods: In a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined associations between pre-diagnostic circulating concentrations of 97 lipid metabolites (acylcarnitines, glycerophospholipids and sphingolipids) and colorectal cancer risk. Circulating lipids were measured using targeted mass spectrometry in 1591 incident colorectal cancer cases (55% women) and 1591 matched controls. Multivariable conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between concentrations of individual lipid metabolites and metabolite patterns with colorectal cancer risk. Findings: Of the 97 assayed lipids, 24 were inversely associated (nominally p < 0.05) with colorectal cancer risk. Hydroxysphingomyelin (SM (OH)) C22:2 (OR per doubling 0.60, 95% CI 0.47-0.77) and acylalkyl-phosphatidylcholine (PC ae) C34:3 (OR per doubling 0.71, 95% CI 0.59-0.87) remained associated after multiple comparisons correction. These associations were unaltered after excluding the first 5 years of follow-up after blood collection and were consistent according to sex, age at diagnosis, BMI, and colorectal subsite. Two lipid patterns, one including 26 phosphatidylcholines and all sphingolipids, and another 30 phosphatidylcholines, were weakly inversely associated with colorectal cancer. Interpretation: Elevated pre-diagnostic circulating levels of SM (OH) C22:2 and PC ae C34:3 and lipid patterns including phosphatidylcholines and sphingolipids were associated with lower colorectal cancer risk. This study may provide insight into potential links between specific lipids and colorectal cancer development. Additional prospective studies are needed to validate the observed associations.

• Jezik: Angleški jezik
• Ključne besede: acylcarnitines, colorectal cancer, glycerophospholipids, lipids, metabolomics, sphingolipids
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 15 str.
• Številčenje: Vol. 101, art. 105024
• PID: 20.500.12556/RUL-182325
• UDK: 61:577
• ISSN pri članku: 2352-3964
• DOI: 10.1016/j.ebiom.2024.105024
• COBISS.SI-ID: 199009283
• Datum objave v RUL: 07.05.2026

Gradivo je del revije

• Naslov: EBioMedicine
• Skrajšan naslov: EBioMedicine
• Založnik: Elsevier
• ISSN: 2352-3964
• COBISS.SI-ID: 523063577

Licence

• Licenca: CC BY-NC-ND 3.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 3.0 Nedoločena
• Povezava: https://creativecommons.org/licenses/by-nc-nd/3.0/deed.sl
• Opis: Dovoljuje kopiranje in razširjanje vsebin v kakršnemkoli mediju in obliki. Primerno morate navesti avtorja, povezavo do licence in označiti spremembe, če so kakšne nastale. To lahko storite na kakršenkoli razumen način, vendar ne na način, ki bi namigoval na to, da dajalec licence podpira vas ali vašo uporabo dela. Te vsebine ne smete uporabiti v komercialne namene. Če vsebino predelate (remixate), uredite ali na njej gradite, spremenjene vsebine ne smete razširjati. Ne smete uporabiti pravnih določil ali tehničnih ukrepov, ki bi pravno omejili ali onemogočilo druge, da bi storili karkoli, kar licenca dovoli.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: acilkarnitini, kolorektalni rak, glicerofosfolipidi, lipidi, metabolomika, sfingolipidi

Projekti

• Financer: World Cancer Research Fund
• Številka projekta: 2013/1002

• Financer: EC - European Commission
• Številka projekta: 313010
• Naslov: BBMRI - Large Prospective Cohorts
• Akronim: BBMRI-LPC