Hypopituitarism and cardiovascular risk

Kraljević, Ivana (avtor), Solak, Mirsala (avtor), Mandić, Ante (avtor), Mlekuš, Katarina (avtor), Raičević, Maja (avtor), Divanović Slato, Anida (avtor), Kovačević, Zlata (avtor), Muzurović, Emir (avtor)

Hypopituitarism, resulting from a partial or complete deficiency of anterior or posterior pituitary hormones, is associated with increased cardiovascular (CV) morbidity and mortality. This heterogeneous endocrinological disorder may arise from various etiologies, including genetic mutations, pituitary tumors, traumatic brain injury, and autoimmune diseases. Hypopituitarism often results in multiple endocrine deficits that contribute to metabolic dysregulation characterized by insulin resistance, dyslipidemia, and increased visceral adiposity, all known risk factors for CV disease (CVD). Additionally, the presence of chronic inflammation and endothelial dysfunction further increases the risk of CVD in these patients. While standard hormone replacement therapy (HRT) is crucial for restoring hormonal balance, it can sometimes have adverse metabolic effects that can exacerbate atherosclerosis and CVD. Emerging evidence suggests that optimizing HRT regimens and addressing specific hormone deficiencies, such as growth hormone and cortisol, may reduce these risks and improve CV outcomes. This review comprehensively analyzes the etiology, pathophysiological mechanisms underlying CV risk in anterior pituitary dysfunction, and treatment strategies to mitigate CV morbidity and mortality in patients with hypopituitarism.

• Jezik: Angleški jezik
• Ključne besede: hypopituitarism, cardiovascular risk, cardiovascular disease, GH deficiency, hormone replacement therapy
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: 22 str.
• Številčenje: Vol. 30
• PID: 20.500.12556/RUL-182308
• UDK: 616.1
• ISSN pri članku: 1940-4034
• DOI: 10.1177/1074248425133239
• COBISS.SI-ID: 275553027
• Datum objave v RUL: 07.05.2026

Gradivo je del revije

• Naslov: Journal of cardiovascular pharmacology and therapeutics
• Založnik: Sage
• ISSN: 1940-4034
• COBISS.SI-ID: 3177236

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: hipopituitarizem, kardiovaskularno tveganje, kardiovaskularna bolezen, pomanjkanje rastnega hormona, nadomestno hormonsko zdravljenje