Heptanuclear zinc(II) complex with metronidazole : synthesis, structure and antibacterial activity

Modec, Barbara (avtor), Podjed Rihtaršič, Nina (avtor), Hrast Rambaher, Martina (avtor), Golob, Majda (avtor)

The reaction systems consisting of mononuclear zinc(II) acetate dihydrate, metronidazole (met) and nitrile solvent (acetonitrile or propionitrile) have afforded heptanuclear zinc(II) compounds, [Zn$_7$O$_2$(CH$_3$COO)$_{10}$(met)$_2$]∙2CH$_3$CN (1) and [Zn$_7$O$_2$(CH$_3$COO)$_{10}$(met)$_2$]∙2CH$_3$CH$_2$CN (2). Heptanuclear compounds 1 and 2 formed regardless of the reaction conditions: either under ambient conditions or when heated at 105 °C for 24 h in autoclaves. Their compositions were authenticated using single crystal X-ray crystallography. Both compounds feature the previously known {Zn$_7$O$_2$(CH$_3$COO)$_{10}$} structural core whose metal ions are interconnected via acetate and μ$_4$-oxide ligands. Two metronidazole ligands are coordinated to this core via imidazole nitrogen atoms. The zinc ions of the heptanuclear complex adopt different coordination environments: four are in nearly tetrahedral environments of four oxygen atoms, two are surrounded by NO$_4$ donor atoms which define vertices of a distorted square pyramid and one is in an octahedral environment of six oxygen atoms. The Znsingle bondO bonding patterns reflect both the nature and the number of donors. The solid-state structures of 1 and 2 display different intermolecular connectivities. Antibacterial testing against a series of Gram-positive and Gram-negative bacteria shows that [Zn$_7$O$_2$(CH$_3$COO)$_{10}$(met)$_2$]∙2CH$_3$CN (1) exhibits moderate activity against Staphylococcus epidermidis. Overall, the study advances the field of metal-based antimicrobial agents and offers new perspectives on addressing antibiotic resistance.

• Jezik: Angleški jezik
• Ključne besede: Zinc(II), Zn$_4$(μ$_4$-O) entity, heptanuclear core, metronidazole, crystal structure, antibacterial activity
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo ; FFA - Fakulteta za farmacijo ; VF - Veterinarska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 8 str.
• Številčenje: Vol. 20, art. 102267
• PID: 20.500.12556/RUL-181550
• UDK: 546.47:615.28
• ISSN pri članku: 2211-7156
• DOI: 10.1016/j.rechem.2025.102962
• COBISS.SI-ID: 262343683
• Datum objave v RUL: 10.04.2026

Gradivo je del revije

• Naslov: Results in chemistry
• Založnik: Elsevier B.V.
• ISSN: 2211-7156
• COBISS.SI-ID: 56332803

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: cink(II), Zn$_4$(μ$_4$-O) entiteta, heptanuklearno jedro, metronidazol, kristalna struktura, antibakterijsko delovanje