Modelling brain metabolism with interacting nonautonomous phase oscillators

Barnes, Samuel J.K. (avtor), Echeverría, Anaí (avtor), Hawley, Joshua (avtor), Suprunenko, Yevhen F. (avtor), Stefanovska, Aneta (avtor)

Traditional brain models have focused primarily on electrical signalling, offering valuable insights but often overlooking the crucial role of metabolism within the neurovascular unit. Existing metabolic models tend to be highly detailed and mass-based, relying on strict conservation laws that limit their applicability to the brain’s thermodynamically open environment. In this study, we present a novel, phenomenological model of neuronal energy metabolism using a network of coupled Kuramoto oscillators. This nonautonomous phase dynamics framework captures complex, time-dependent interactions and allows for multiple synchronization states among metabolic processes. Our model captures key features consistent with healthy neurovascular dynamics, despite not being directly fitted to empirical data from resting-state brains and reveals how disruptions in metabolic synchrony may contribute to dementia-related pathology. By emphasizing the importance of metabolic coordination in the neurovascular unit, this work provides a versatile methodological foundation for future brain modelling efforts.

• Jezik: Angleški jezik
• Ključne besede: astrocyte, brain, coupled oscillators, metabolism, network physiology, neurovascular unit, nonautonomous systems, phase dynamics
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FE - Fakulteta za elektrotehniko
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 14 str.
• Številčenje: Vol. 6
• PID: 20.500.12556/RUL-179844
• UDK: 621.373:612
• ISSN pri članku: 2674-0109
• DOI: 10.3389/fnetp.2026.1720336
• COBISS.SI-ID: 269647363
• Datum objave v RUL: 25.02.2026

Gradivo je del revije

• Naslov: Frontiers in network physiology
• Skrajšan naslov: Front. netw. physiol.
• Založnik: Frontiers Media SA
• ISSN: 2674-0109
• COBISS.SI-ID: 75774211

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: astrocit, možgani, povezani nihalniki, presnova, fiziologija mreže, nevrovaskularna enota, neavtonomni sistemi, fazna dinamika

Projekti

• Financer: UKRI - UK Research and Innovation
• Številka projekta: EP/M006298/1
• Naslov: A device to detect and measure the progression of dementia by quantifying the interactions between neuronal and cardiovascular oscillations

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P2-0232
• Naslov: Analiza biomedicinskih slik in signalov