The effect of bisphenol PH and seven other bisphenol A alternatives on human haemostasis in vitro

Hrubša, Marcel (avtor), Soloviova, Alina (avtor), Harčárová, Patrícia (avtor), Gunaseelan, Catherine (avtor), Lomozová, Zuzana (avtor), Jirkovský, Eduard (avtor), Carazo, Alejandro (avtor), Sollner Dolenc, Marija (avtor), Peterlin-Mašič, Lucija (avtor), Mladěnka, Přemysl (avtor)

Recognition of bisphenol A’s toxicity has meant substitution by new analogues, which are poorly investigated. We determined the impact of bisphenol A and 8 of its analogues on platelet aggregation, coagulation, and their toxicity to erythrocytes. Erythrocyte lysis assays revealed bisphenol toxicity towards both human and rat erythrocytes with high TC$_{50s}$> 100 μM. Bisphenol A and bisphenol PH acted as antiplatelet compounds. Bisphenol PH was particularly potent (IC$_{50}$ of 0.42 ± 0.14 μM; 0.16 ± 0.05 μg/ml) in arachidonic acid-based platelet aggregation. Mechanistically, bisphenol PH blocked cyclooxygenase 1, in a similar manner to the antiplatelet drug acetylsalicylic acid. In terms of the coagulation cascade, only weak effects were found for some of the selected compounds, and the tested bisphenols did not impact coagulation or demonstrate erythrocytic toxicity at biologically achievable concentrations. Contrarily, the negative impact of bisphenol PH on platelets, with a possible subsequent risk of bleeding, might have biological relevance.

• Jezik: Angleški jezik
• Ključne besede: bisphenol, cytotoxicity, haemostasis, cyclooxygenase, platelet
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2026
• Št. strani: 1-9 str.
• Številčenje: Vol. 121, [art. no.] ǂ104897
• PID: 20.500.12556/RUL-179102
• UDK: 615.9:612.43:620.266.1
• ISSN pri članku: 1872-7077
• DOI: 10.1016/j.etap.2025.104897
• COBISS.SI-ID: 260908547
• Datum objave v RUL: 05.02.2026

Gradivo je del revije

• Naslov: Environmental toxicology and pharmacology
• Založnik: Elsevier
• ISSN: 1872-7077
• COBISS.SI-ID: 175280899

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: bisfenol, citotoksičnost, hemostaza, ciklooksigenaza, trombociti, toksikologija, endokrini vidik, hemostaza, strjevanje krvi, antikoagulacijsko zdravljenje, terapija z zdravili