Coupling anisotropic curvature and nematic order : mechanisms of membrane shape remodeling

Ravid, Yoav (avtor), Penič, Samo (avtor), Mesarec, Luka (avtor), Gov, Nir S. (avtor), Kralj-Iglič, Veronika (avtor), Iglič, Aleš (avtor), Drab, Mitja (avtor)

This study theoretically investigates how anisotropic curved membrane components (CMCs) control vesicle morphology through curvature sensing, nematic alignment, topological defects and volume constraints. By comparing arc- and saddle-shaped CMCs, we identify a rich spectrum of steady-state phases. For fully CMC-covered vesicles, arc-shaped components drive a pearling-to-cylinder transition as nematic interactions strengthen, while on partially CMC-covered vesicles the saddle-shaped CMCs stabilize necks between the convex regions of bare membrane. We map the steady-state shapes of vesicles partially covered by arc- and saddle-shaped CMCs, exposing how different vesicle shapes depend on the interplay between nematic interactions and volume constraints, revealing several novel phases. By investigating the in-plane nematic field, we find that topological defects consistently localize to high-curvature regions, revealing how intrinsic and deviatoric curvature effects cooperate in membrane remodeling. These findings establish a unified framework for understanding how proteins and lipid domains with anisotropic intrinsic curvature shape cellular structures—from organelle morphogenesis to global cell shape.

• Jezik: Angleški jezik
• Ključne besede: lipid bilayer, simulations, Monte-Carlo, curvature, cells
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FE - Fakulteta za elektrotehniko; ZF - Zdravstvena fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: Str. 8407-8428
• Številčenje: Vol. 21, no. 44
• PID: 20.500.12556/RUL-177997
• UDK: 577
• ISSN pri članku: 1744-6848
• DOI: 10.1039/D5SM00620A
• COBISS.SI-ID: 248952579
• Datum objave v RUL: 15.01.2026

Gradivo je del revije

• Naslov: Soft matter
• Skrajšan naslov: Soft matter
• Založnik: Royal Society of Chemistry
• ISSN: 1744-6848
• COBISS.SI-ID: 23741223

Licence

• Licenca: CC BY-NC 3.0, Creative Commons Priznanje avtorstva-Nekomercialno 3.0 Nedoločena
• Povezava: https://creativecommons.org/licenses/by-nc/3.0/deed.sl
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Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: lipidni dvosloj, simulacije, Monte-Carlo, ukrivljenost, celice