Six-membered N-heteroarenes (“6NHetAr”) play pivotal roles in the pharmaceutical, agrochemical, and materials science industries. In recent times, deuterium (D)-labelled 6NHetAr have demonstrated enhanced performance over their unlabelled counterparts. For example, VV116 and VX-984, approved therapeutics for the treatment of COVID-19 and cancer, and deuterated functional materials for use as ligands in catalysts and organometallic light-emitters. As interest in this field continues to grow, there is a corresponding need to develop more efficient, scalable, and sustainable approaches to deuterate 6NHetAr. In this work, we comprehensively review approaches developed for the incorporation of D into 6NHetAr, their fused counterparts, and complex compounds containing 6NHetAr. We also provide an overview of established and emerging applications for these materials.
| Jezik: | Angleški jezik |
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| Ključne besede: | deuteration, deuterium, deuterium-labelling, isotope-labelling, N-heteroarene, N-heteroaromatic compounds, pyridine, pyrimidine, pyrazine, pyridazine, quinoline, quinazoline, electron deficiency, triazine, tetrazine, organic electronics, pharmaceuticals, dyes, heteroaromatics, regioselectivity |
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| Vrsta gradiva: | Članek v reviji |
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| Tipologija: | 1.02 - Pregledni znanstveni članek |
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| Organizacija: | FKKT - Fakulteta za kemijo in kemijsko tehnologijo
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| Status publikacije: | Objavljeno |
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| Različica publikacije: | Objavljena publikacija |
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| Leto izida: | 2025 |
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| Št. strani: | 55 str. |
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| Številčenje: | Vol. 31, iss. 67, art. e02659 |
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| PID: | 20.500.12556/RUL-175821  |
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| UDK: | 547.8:546.11.027*2 |
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| ISSN pri članku: | 0947-6539 |
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| DOI: | 10.1002/chem.202502659 |
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| COBISS.SI-ID: | 255671299 |
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| Datum objave v RUL: | 10.11.2025 |
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| Število ogledov: | 103 |
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| Število prenosov: | 30 |
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| Metapodatki: |    |
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