Introduction: A gastrostomy is a surgically created access to the stomach that enables long-term enteral nutrition in patients who are unable to ingest food orally but have a functioning gastrointestinal tract. The nurse plays a key role throughout the care process, including the technical execution of feeding, patient and caregiver education, monitoring of feeding tolerance and the management of complications, as well as ensuring proper hygiene and handling of feeding equipment. Purpose: The purpose of this thesis is to explore and present the nurse’s responsibilities in feeding via gastrostomy and to highlight the most common challenges in clinical practice. Methods: A descriptive method was used, supported by a systematic review of professional and scientific literature published between 2012 and 2025 searched in scientific databases PubMed, COBISS.SI in Google Scholar. A total of 13 articles were included in the final analysis, based on content relevance and methodological criteria. Results: Nurses play a central role in patient preparation, feeding implementation, stoma care, medication administration, complication recognition, and education. Challenges include a lack of standardized guidelines, limited educational resources, and organizational difficulties during the transition to home care. Discussion: The findings emphasize the need for interdisciplinary teamwork, standardized procedures, and continuous education. Psychosocial support and an individualized approach significantly influence therapy outcomes. Conclusion: The nurse’s responsibilities in gastrostomy feeding are complex and require professional knowledge, communication skills, and systemic support. Improving the quality of care depends on developing clinical protocols, enhanci
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