Postprandial time in tight range with faster insulin aspart compared with standard insulin aspart in youth with type 1 diabetes using automated insulin delivery

Dovč, Klemen (avtor), Spanbauer, Charles (avtor), Chiarle, Eleonora (avtor), Bratina, Nataša (avtor), Fröhlich-Reiterer, Elke (avtor), Potočnik, Nejka (avtor), Zaharieva, Dessi P. (avtor), Hropot, Tim (avtor), Fritsch, Maria (avtor), Calhoun, Peter (avtor), Battelino, Tadej (avtor)

Aims: The aim of this study was to assess postprandial glycaemic outcomes using automated insulin delivery with faster acting insulin aspart (FIA) or standard insulin aspart (SIA) over 4 weeks in youth (aged 10–18 years) with type 1 diabetes. Materials and Methods: We undertook a secondary analysis of postprandial glycaemic outcomes from a double-blind, randomised, crossover study comparing FIA to SIA using an investigational version of MiniMed™ 780G. Endpoints included postprandial time in tight range (70–140 mg/dL; TITR), postprandial glucose excursions and peak glucose, and incremental area under curve (iAUC). Results: The mean ± SD age of 30 included participants was 15.0 ± 1.7 years, 47% were male, mean HbA1c was 7.5% ± 0.9% (58 ± 9.8 mmol/mol) and the number of meals per day per participant was 3.2 ± 1.2 meals. Overall, the postprandial outcomes were improved with FIA compared with SIA. Mean glucose at the start of the meal was 151 mg/dL in the FIA group and reached a peak glucose of 194 mg/dL, compared with starting level of 151 mg/dL in the SIA group and a peak of 198 mg/dL (difference in excursion: −3.8 mg/dL; 95% confidence interval −5.8 to −1.7; p <0.001). FIA group also had a 1.9% increase in mean TITR (p = 0.02) and a 2.0-mg/dL decrease in mean iAUC (p = 0.003). Differences in outcomes were the most noticeable for breakfast, meals with a larger amount of carbohydrates (>45 g) and participants with lower insulin-to-carbohydrate ratios. Conclusions: Faster insulin formulation with AID improved postprandial glycaemic outcomes and could be a useful therapeutical option in youth with type 1 diabetes that have challenges achieving glycaemic targets.

• Jezik: Angleški jezik
• Ključne besede: postprandial time in tight, range standard insulin aspart in youth with type 1, automated insulin delivery, continuous glucose monitoring, CGM, glycaemic control, insulin therapy, type 1 diabetes
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: Str. 2147-2153
• Številčenje: Vol. 27, iss. 4
• PID: 20.500.12556/RUL-169060
• UDK: 616.379
• ISSN pri članku: 1462-8902
• DOI: 10.1111/dom.16211
• COBISS.SI-ID: 235096323
• Datum objave v RUL: 09.05.2025

Gradivo je del revije

• Naslov: Diabetes, obesity and metabolism
• Skrajšan naslov: Diabetes obes. metab.
• Založnik: Wiley
• ISSN: 1462-8902
• COBISS.SI-ID: 13290713

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.