Introduction: CAR T-cell therapy has become one of the most promising approaches in modern oncology over the past decade, especially in the treatment of hematological malignancies such as leukaemias and lymphomas. This advanced approach involves the use of the patient's own T cells, which are genetically modified to target and destroy cancer cells. Purpose: The purpose of this thesis is to comprehensively explore and present the role of nurses in the CAR T-cell therapy process, with a particular focus on the identification and management of side effects such as cytokine release syndrome (CRS) and neurotoxicity. Methods: The thesis is based on a descriptive analysis of the literature, reviewing relevant scientific articles and professional guidelines dealing with CAR T-cell therapy and the role of nurses in this process. Results: The results show that nurses play a key role in all phases of CAR T-cell therapy, from patient preparation, through the implementation of therapy, to the monitoring and management of potential compliactions. Their role is crucial to ensure the safety and efficacy of therapy, which also includes continuous education and support for patients and their families. Discussion and conclusion: The thesis emphasises the importance of close monitoring of patients, identification and management of side effects and enursing safe implementation of CAR-T therapy. These aspects are very important to improve the quality o care and the success of the treatment. The role of nurses is indispensable in this respect, as their expertise and competence contribute significantly to patient safety and treatment effectiveness. The results highlight the need for further professional development and specialisation of nurses in this area.
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