Antimicrobial activity of poly(methyl methacrylate) doped with CuO and ZnO nanoparticles

Matijaković Mlinarić, Nives (avtor), Zore, Anamarija (avtor), Veselinović, Valentina (avtor), Trtić, Nataša (avtor), Dolić, Olivera (avtor), Štukelj, Roman (avtor), Abram, Anže (avtor), Učakar, Aleksander (avtor), Adamović, Tijana (avtor), Vidrih, Rajko (avtor), Rojko, Franc (avtor), Kasemets, Kaja (avtor), Kahru, Anne (avtor), Bohinc, Klemen (avtor)

Oral health represents a significant factor in general health and life quality. A significant number of people are affected by tooth loss during their lifetimes, especially in the older population. Poly(methyl methacrylate) (PMMA) resins are the preferred option for replacing missing teeth due to the material stability, easy handling, low toxicity, and most importantly biocompatibility with human tissue. Even though PMMA is the preferable material for denture preparation, it is susceptible to microbial colonization, which can induce the development of oral infections. This study aimed to increase the antimicrobial effect of PMMA and compare the antimicrobial properties of PMMA incorporated with different amounts (2 and 5 wt %) of zinc oxide (ZnO; primary size 62.4 nm ± 16.7 nm) and copper oxide (CuO; primary size 434.0 nm ± 118.5 nm) nanoparticles to determine their antimicrobial effects on Gram-positive bacteria Staphylococcus aureus and yeast Candida albicans─pathogenic microbes often found on dentures. To understand the adhesion of microorganisms to PMMA-modified surfaces, the following surface properties were measured: roughness, contact angle, and ζ potential. In addition, CIE (the International Commission on Illumination) color parameters of the materials were determined. The bacterial adhesion was measured by viable plate counts and scanning electron microscopy. Our study showed that 5 wt % ZnO added to PMMA yields a promising denture material that is esthetically acceptable and shows antimicrobial properties toward both, Staphylococcus aureus and Candida albicans.

• Jezik: Angleški jezik
• Ključne besede: metal oxide nanoparticles, nanoparticles, oral health, organic compounds, oxides, dentures, color
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: ZF - Zdravstvena fakulteta ; BF - Biotehniška fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: Str. 13060-13072
• Številčenje: Vol. 10, iss. 13
• PID: 20.500.12556/RUL-168414
• UDK: 544
• ISSN pri članku: 2470-1343
• DOI: 10.1021/acsomega.4c10170
• COBISS.SI-ID: 232333315
• Datum objave v RUL: 11.04.2025

Gradivo je del revije

• Naslov: ACS omega
• Skrajšan naslov: ACS omega
• Založnik: American Chemical Society
• ISSN: 2470-1343
• COBISS.SI-ID: 525873945

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.