Ex vivo electrophysiological evaluation of peripheral nerve functioning following exposition of adult mice to the organophosphorus pesticide chlormephos

Frangež, Robert (avtor), Benoit, Evelyne (avtor)

The organophosphorus pesticide chlormephos was tested for its potential peripheral neurotoxicity by analyzing the diphasic compound action potential (CAP) of sciatic nerves isolated from adult mice chronically exposed to a sub-lethal dose of this pesticide, compared with control age-matched animals being only exposed to the vehicle. No significant modification was detected between chlormephos-exposed and control groups in their nerve responsiveness to stimulus. Furthermore, similar values of CAP kinetic variables were obtained from the two mouse groups. Finally, no abnormality concerning CAP refractory periods and responsiveness to high frequency stimulation (nerve fatigue) was exhibited by chlormephos-treated mice, when compared with control animals. These results complicate the screening for the potential neurotoxicity of organophosphates since they support the contention that the peripheral neuropathy induced by chronical exposition to sub-lethal doses of chlormephos is species dependents does not necessary correlate well with the clinical signs observed at the central nervous system level.

• Jezik: Angleški jezik
• Ključne besede: chlormephos, organophosphorus pesticide, chronical oral administration, mouse sciatic nerve, diphasic compound action potential, ex vivo electrophysiology
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: VF - Veterinarska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: 7 str.
• Številčenje: Vol. 114, art. 104645
• PID: 20.500.12556/RUL-166930
• UDK: 591:636.09
• ISSN pri članku: 1872-7077
• DOI: 10.1016/j.etap.2025.104645
• COBISS.SI-ID: 224130563
• Datum objave v RUL: 31.01.2025

Gradivo je del revije

• Naslov: Environmental toxicology and pharmacology
• Založnik: ElsevierBV
• ISSN: 1872-7077
• COBISS.SI-ID: 175280899

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P4-0053
• Naslov: Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: Bilateral Slovenian/French Proteus Program
• Številka projekta: BI-FR-21-22-PROTEUS-002/46143VH