Management of patients with venous thromboembolism and a high recurrence risk estimated by the Vienna Prediction Model: a prospective cohort study

Šinkovec, Hana (avtor), Kyrle, Paul A. (avtor), Eischer, Lisbeth (avtor), Gressenberger, Paul (avtor), Gary, Thomas (avtor), Brodmann, Marianne (avtor), Heinze, Georg (avtor), Eichinger, Sabine (avtor)

Background: The Vienna Prediction Model (VPM) identifies patients with a first unprovoked deep vein thrombosis of the leg and/or pulmonary embolism who have a low recurrence risk and may, therefore, not benefit from extended-phase anticoagulation. Objectives: The aim of this study was to evaluate patients with a predicted high risk of recurrent venous thromboembolism (VTE). Methods and Results: We prospectively followed 266 patients in whom the VPM had predicted a recurrence risk of more than 5.5% at 1 year for a median of 13.5 months. Their median age was 56 years, and 96% were men. After the VPM risk assessment, 196 patients restarted anticoagulation. While on anticoagulation, none of the patients experienced recurrent VTE, whereas 4 patients had nonmajor clinically relevant bleeding (absolute bleeding rate, 1.8 [95% CI, 0.5-4.5] events per 100 patient-years). Seventy patients were left untreated after VPM risk assessment for various reasons. Among patients not using anticoagulation, 15 had recurrence (absolute recurrence rate, 18.1 [95% CI, 10.1, 29.9] events per 100 person-years). According to the extended Kaplan–Meier analysis, the probability of VTE recurrence in patients not on anticoagulation was 10.1% and 17.9% at 6 and 12 months after VPM risk assessment, respectively. Conclusion: Anticoagulant therapy is effective and safe in patients with an unprovoked VTE, in whom the VPM had predicted a high risk of recurrent VTE. If these patients are left untreated, the risk of recurrence is high.

• Jezik: Angleški jezik
• Ključne besede: deep vein thrombosis, pulmonary embolism, venous thromboembolism, Vienna Prediction Model recurrence
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: BF - Biotehniška fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2025
• Št. strani: 6 str.
• Številčenje: Vol. 9, iss. 1, art. 102649
• PID: 20.500.12556/RUL-166312
• UDK: 616.1
• ISSN pri članku: 2475-0379
• DOI: 10.1016/j.rpth.2024.102649
• COBISS.SI-ID: 221026307
• Datum objave v RUL: 07.01.2025

Gradivo je del revije

• Naslov: Research and Practice in Thrombosis and Haemostasis
• Založnik: Wiley
• ISSN: 2475-0379
• COBISS.SI-ID: 4091820

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: globoka venska tromboza, pljučna embolija, venska trombembolija

Projekti

• Financer: FWF - Austrian Science Fund
• Številka projekta: KLIF316