Depressive disorder and antidepressants from an epigenetic point of view

Šalamon Arčan, Iris (avtor), Kouter, Katarina (avtor), Videtič Paska, Alja (avtor)

Depressive disorder is a complex, heterogeneous disease that affects approximately 280 million people worldwide. Environmental, genetic, and neurobiological factors contribute to the depressive state. Since the nervous system is susceptible to shifts in activity of epigenetic modifiers, these allow for significant plasticity and response to rapid changes in the environment. Among the most studied epigenetic modifications in depressive disorder is DNA methylation, with findings centered on the brain-derived neurotrophic factor gene, the glucocorticoid receptor gene, and the serotonin transporter gene. In order to identify biomarkers that would be useful in clinical settings, for diagnosis and for treatment response, further research on antidepressants and alterations they cause in the epigenetic landscape throughout the genome is needed. Studies on cornerstone antidepressants, such as selective serotonin reuptake inhibitors, selective serotonin and norepinephrine reuptake inhibitors, norepinephrine, and dopamine reuptake inhibitors and their effects on depressive disorder are available, but systematic conclusions on their effects are still hard to draw due to the highly heterogeneous nature of the studies. In addition, two novel drugs, ketamine and esketamine, are being investigated particularly in association with treatment of resistant depression, which is one of the hot topics of contemporary research and the field of precision psychiatry.

• Jezik: Angleški jezik
• Ključne besede: depression, epigenetics, DNA methylation, histone tail modification, microRNA, antidepressant
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: Str. 1150-1168
• Številčenje: Vol. 12, iss. 9
• PID: 20.500.12556/RUL-165244
• UDK: 616.89
• ISSN pri članku: 2220-3206
• DOI: 10.5498/wjp.v12.i9.1150
• COBISS.SI-ID: 122214915
• Datum objave v RUL: 28.11.2024

Gradivo je del revije

• Naslov: World journal of psychiatry
• Skrajšan naslov: World j. psychiatry
• Založnik: Baishideng Publishing Group
• ISSN: 2220-3206
• COBISS.SI-ID: 1537103300

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: depresija, epigenetika, metilacija DNA

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Program financ.: Young researchers

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0390
• Naslov: Funkcijska genomika in biotehnologija za zdravje