Epigenetics in psychiatry : beyond DNA methylation

Kouter, Katarina (avtor), Šalamon Arčan, Iris (avtor), Videtič Paska, Alja (avtor)

The global burden of psychopathologies appears to be underestimated, since the global psychiatric disorder burden is exceeding other medical burdens. To be able to address this problem more effectively, we need to better understand the etiology of psychiatric disorders. One of the hallmarks of psychiatric disorders appears to be epigenetic dysregulation. While some epigenetic modifications (such as DNA methylation) are well known and studied, the roles of others have been investigated much less. DNA hydroxymethylation is a rarely studied epigenetic modification, which as well as being an intermediate stage in the DNA demethylation cycle is also an independent steady cell state involved in neuro- development and plasticity. In contrast to DNA methylation, DNA hydroxymethylation appears to be related to an increase in gene expression and subsequent protein expression. Although no particular gene or genetic locus can be at this point linked to changes in DNA hydroxymethylation in psychiatric disorders, the epigenetic marks present good potential for biomarker identification because the epigenetic landscape is a result of the interplay between genes and environment, which both influence the development of psychiatric disorders, and because hydroxymethylation changes are particularly enriched in the brain and in synapse-related genes.

• Jezik: Angleški jezik
• Ključne besede: mood disorders, suicide, schizophrenia, bipolar disorder, hydroxymethylation, 5-hydroxymethycytosine, gene expression
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: Str. 319-330
• Številčenje: Vol. 13, iss. 6
• PID: 20.500.12556/RUL-165213
• UDK: 616.89
• ISSN pri članku: 2220-3206
• DOI: 10.5498/wjp.v13.i6.319
• COBISS.SI-ID: 156170755
• Datum objave v RUL: 27.11.2024

Gradivo je del revije

• Naslov: World journal of psychiatry
• Skrajšan naslov: World j. psychiatry
• Založnik: Baishideng Publishing Group
• ISSN: 2220-3206
• COBISS.SI-ID: 1537103300

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: motnje razpoloženja, samomor, shizofrenija, bipolarna motnja, hidroksimetilacija, 5-hidroksi-metil‐citozin, izražanje genov