Titanium dioxide substrates as sensors for detection of platelets and extracellular particles from blood plasma

Rawat, Niharika (avtor), Junkar, Ita (avtor), Benčina, Metka (avtor), Lampe, Tomaž (avtor), Kralj-Iglič, Veronika (avtor), Iglič, Aleš (avtor)

Biosensors are pivotal in biomedical applications, particularly for disease detection, diagnosis, treatment, health management, and monitoring. Titanium dioxide (TiO2) is a prominent material for biosensors due to its biocompatibility, corrosion resistance, and availability in various nanostructured forms. This study explores the interaction of platelets and extracellular vesicles (EVs) with different TiO2 surface morphologies using flow cytometry (FCM) and scanning electron microscopy (SEM). Blood plasma samples were incubated with various TiO2 surfaces to evaluate particle counts and characteristics. FCM results indicated a higher abundance of platelets compared to EVs, with significant fragmentation observed post-centrifugation. SEM analysis confirmed platelet activation and fragmentation, with the microflowered TiO2 surface displaying fewer vesicles due to its rough topography. The findings suggest that while TiO2 surface structuring minimally impacts particle counts, it influences platelet and EV interactions, highlighting the need for advanced detection techniques and further investigation into surface interactions.

• Jezik: Angleški jezik
• Ključne besede: cold gaseous plasma, atmospheric pressure plasma, plasma technology, dental medicine, extracellular vesicles, surface treatment
• Vrsta gradiva: Drugo
• Tipologija: 1.08 - Objavljeni znanstveni prispevek na konferenci
• Organizacija: ZF - Zdravstvena fakulteta ; FE - Fakulteta za elektrotehniko
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: Str. 92-101
• PID: 20.500.12556/RUL-163381
• UDK: 577:616.15
• DOI: 10.55295/PSL.11.2024.11
• COBISS.SI-ID: 210339587
• Datum objave v RUL: 04.10.2024

Gradivo je del monografije

• Naslov: Socratic Lectures : 11th international symposium, Ljubljana, 8. June 2024
• Uredniki: Veronika Kralj-Iglič, Yelena Istileulova, Anna Romolo
• Kraj izida: Ljubljana
• Založnik: University of Ljubljana Press
• Leto izida: 2024
• ISBN: 978-961-297-383-4
• COBISS.SI-ID: 205044227

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.