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N-acetylcysteine ineffective in alleviating hangover from binge drinking : a clinical study
ID Podobnik, Boris (Avtor), ID Demšar, Lenart (Avtor), ID Šarc, Lucija (Avtor), ID Jerin, Aleš (Avtor), ID Osredkar, Joško (Avtor), ID Trontelj, Jurij (Avtor), ID Roškar, Robert (Avtor), ID Brvar, Miran (Avtor)

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URLURL - Izvorni URL, za dostop obiščite https://www.mdpi.com/2305-6304/12/8/585 Povezava se odpre v novem oknu

Izvleček
Alcohol hangover (veisalgia) is a fairly common phenomenon. The pathogenesis of veisalgia is not understood and treatment has not yet been established. Occasionally, students take N-acetylcysteine (NAC) before binge drinking to alleviate hangover. The aim of this study was to evaluate the effect of NAC on serum levels of electrolytes, enzymes, oxidative stress biomarkers and symptoms of veisalgia in binge drinking. In this randomized, double-blind, placebo-controlled study, healthy students were randomly assigned into two groups: one receiving NAC and the other receiving a placebo. Blood samples were taken before drinking, 30 min after a 1.5 h long drinking session, and the subsequent morning. Serum levels of electrolytes, urea, enzymes, ethanol, 8-Hydroxydeoxyguanosine (8-OHdG) and N-epsilon-hexanoyl-lysine were measured. The participants completed the Acute Hangover Severity Scale (AHSS) assessment based on symptoms, and 40 students (20 male), aged 23 ± 2 years, were included in the study. Their mean blood ethanol concentration was 1.4 g/kg. Serum sodium levels were increased after drinking, and urea decreased the following morning compared to their levels before drinking in both groups. Serum 8-OHdG levels were increased after drinking and remained elevated until the following morning, compared to the levels before drinking, in both groups. NAC had no effect on sodium, urea and 8-OHdG levels or the symptoms of veisalgia. In conclusion, binge drinking causes a transient increase in serum sodium and as a prolonged increase in oxidative marker 8-OHdG levels. NAC had no effect on the sodium and 8-OHdG levels.

Jezik:Angleški jezik
Ključne besede:alcohol, hangover, veisalgia, NAC, sodium, dehydration, oxidative markers
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FFA - Fakulteta za farmacijo
MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2024
Št. strani:9 str.
Številčenje:Vol. 12, iss. 8, art. 585
PID:20.500.12556/RUL-162174 Povezava se odpre v novem oknu
UDK:613.81+616.151.1-08
ISSN pri članku:2305-6304
DOI:10.3390/toxics12080585 Povezava se odpre v novem oknu
COBISS.SI-ID:206065923 Povezava se odpre v novem oknu
Datum objave v RUL:19.09.2024
Število ogledov:171
Število prenosov:23
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Toxics : Elektronski vir
Skrajšan naslov:Toxics
Založnik:MDPI
ISSN:2305-6304
COBISS.SI-ID:520262681 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:alkohol, veisalgija, NAC, natrij, oksidativni markerji, alkoholni maček, dehidracija

Projekti

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P3-0019
Naslov:Aplikativna in bazična fiziologija in patofiziologija v medicini

Financer:Drugi - Drug financer ali več financerjev
Program financ.:University Medical Centre Ljubljana
Številka projekta:20200175

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