Introduction: The liver is a key organ for metabolism and immune regulation, and is important for many physiological processes. Liver cancer, particularly hepatocellular cancer, is a major public health problem, especially in the male population. Magnetic resonance imaging is an effective tool for the detection and characterization of hepatocellular cancer, allowing an accurate diagnosis. Optimisation of imaging protocols with specific contrast agents can improve the quality of liver imaging and the accuracy of hepatocellular cancer diagnosis. Purpose: The aim is to provide a more detailed description of the anatomy, liver diseases and the performance of liver magnetic resonance with a hepatospecific contrast agent. We have also been present at the performance of this type of examination in clinical practice, which allowed us to analyze and compare the magnetic resonance protocol used with the international guidelines of the European Association for Digestive and Abdominal Diseases. Methods: We collected the literature on liver magnetic resonance with hepatospecific contrast agent. We monitored the performance of the tests in clinical practice and compared the protocols with international guidelines. Enrolled patients received Primovist as a contrast agent and a drug to reduce intestinal peristalsis before the examination. The examination protocols were selected according to the needs and technical characteristics of the device and the recommendations of the institution. Results: Magnetic resonance images of the liver with a hepatospecific contrast agent were shown, where images were obtained by performing pulse sequences in different planes. In addition, we showed the presence of two pathological conditions. Discussion and conclusion: The guidelines of the European Association for Gastrointestinal and Abdominal Radiology for magnetic resonance imaging of the liver with hepatospecific contrast agents are aligned with the protocol at the Dvorec Lanovž Specialist Clinic. This enables precise and comprehensive liver examination, aiding in the detection of pathologies such as focal nodular hyperplasia and hepatocellular carcinoma. The hepatocellular phase is crucial, as maximal differentiation between healthy and pathological liver tissue is achieved within 20 minutes of hepatospecific contrast agent application.
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