Multifunctional roles of γ-enolase in the central nervous system : more than a neuronal marker

Horvat, Selena (avtor), Kos, Janko (avtor), Pišlar, Anja (avtor)

Enolase, a multifunctional protein with diverse isoforms, has generally been recognized for its primary roles in glycolysis and gluconeogenesis. The shift in isoform expression from α-enolase to neuron-specific γ-enolase extends beyond its enzymatic role. Enolase is essential for neuronal survival, differentiation, and the maturation of neurons and glial cells in the central nervous system. Neuron-specific γ-enolase is a critical biomarker for neurodegenerative pathologies and neurological conditions, not only indicating disease but also participating in nerve cell formation and neuroprotection and exhibiting neurotrophic-like properties. These properties are precisely regulated by cysteine peptidase cathepsin X and scaffold protein γ1-syntrophin. Our findings suggest that γ-enolase, specifically its C-terminal part, may offer neuroprotective benefits against neurotoxicity seen in Alzheimer's and Parkinson's disease. Furthermore, although the therapeutic potential of γ-enolase seems promising, the effectiveness of enolase inhibitors is under debate. This paper reviews the research on the roles of γ-enolase in the central nervous system, especially in pathophysiological events and the regulation of neurodegenerative diseases.

• Jezik: Angleški jezik
• Ključne besede: γ-enolase, neuronal marker, neurotrophic-like factor, neurodegeneration, neuroprotection
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 16 str.
• Številčenje: Vol. 14, article no. 61
• PID: 20.500.12556/RUL-161035-55979da3-d87c-d1ef-8f7b-af8b3cad1f01
• UDK: 616.8
• ISSN pri članku: 2045-3701
• DOI: 10.1186/s13578-024-01240-6
• COBISS.SI-ID: 197795331
• Datum objave v RUL: 06.09.2024

Gradivo je del revije

• Naslov: Cell & bioscience
• Skrajšan naslov: Cell biosci.
• Založnik: BioMed Central
• ISSN: 2045-3701
• COBISS.SI-ID: 523024665

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: γ-enolaza, nevronski marker, nevrotrofični faktorji, nevrodegeneracija, nevroprotekcija, biomarkerji, nevrologija

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P4-0127
• Naslov: Farmacevtska biotehnologija: znanost za zdravje