The correlation between the triglyceride-glucose index and coagulation markers in patients with recent acute myocardial infarction

Košuta, Daniel (avtor), Novaković, Marko (avtor), Božič, Mojca (avtor), Jug, Borut (avtor)

Background: Metabolic abnormalities and hypercoagulability seem to have an important predictive role in patients with coronary artery disease (CAD). The triglyceride-glucose (TyG) index has emerged as a good marker for metabolic syndrome with predictive value for cardiovascular events. Overall haemostatic potential (OHP) is a reliable global haemostatic essay to identify hypercoagulability in CAD patients. The aim of our study was therefore to evaluate a possible correlation between the TyG index and haemostatic derangements in patients with CAD. Methods: Consecutive patients referred for the first follow-up visit after acute myocardial infarction between December 1, 2018, and March 31, 2020, and did not meet exclusion criteria were included. We determined OHP, overall coagulation potential (OCP), overall fibrinolytic potential (OFP), fibrinogen, D-dimer, and von Willebrand factor from peripheral blood samples. The TyG index was calculated with the previously described and validated formula. Linear regression models were constructed for the multivariate analysis. Results: A total of 117 patients (mean age 56 ± 10 years, 20% women) were included. A correlation was found between TyG index and OCP (r = 0.229, p = 0.026), TyG index and OHP (r = 0.202, p = 0.050), and TyG index and fibrinogen (r = 0.271, p = 0.005). In the multivariate model which accounted for sex, age, and BMI, the correlation between TyG index and OCP (R$^2$ 0.108; ANOVA for regression p = 0.035; beta 2.08 [0.79-4.01], p = 0.042) and between TyG index and fibrinogen (R$^2$ 0.11; ANOVA for regression p = 0.015; beta 0.35 [0.08-0.62], p = 0.012) emerged as statistically significant. Conclusion: The TyG index, a marker of metabolic syndrome, has a strong correlation with a hypercoagulability state in CAD, as determined by the OCP and higher fibrinogen levels. Our findings suggest that metabolic syndrome may be an important driver of atherothrombotic risk in patients with CAD.

• Jezik: Angleški jezik
• Ključne besede: coronary artery disease, acute myocardial infarction, triglyceride-glucose index
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta ; FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 6 str.
• Številčenje: Vol. 2022, art. 6206802
• PID: 20.500.12556/RUL-152337
• UDK: 616.1
• ISSN pri članku: 1875-8630
• DOI: 10.1155/2022/6206802
• COBISS.SI-ID: 141952515
• Datum objave v RUL: 21.11.2023

Gradivo je del revije

• Naslov: Disease markers
• Založnik: Hindawi
• ISSN: 1875-8630
• COBISS.SI-ID: 516120089

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: bolezen koronarnih arterij, akutni miokardni infarkt, indeks trigliceridov in glukoze

Projekti

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: University Medical Centre Ljubljana, Intern tertiary grant

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: V3-2104
• Naslov: Sekundarna preventiva in kakovosti oskrbe po srčnem infarktu v slovenskih bolnišnicah ter analiza vpliva epidemije covid-19 na obravnavo aterosklerotične bolezni