Influence of fused deposition modelling printing parameters on tablet disintegration times : a design of experiments study

Kreft, Klemen (avtor), Stanić Ljubin, Tijana (avtor), Perhavec, Petra (avtor), Dreu, Rok (avtor), Lavrič, Zoran (avtor)

Despite the importance of process parameters in the printing of solid dosage forms using fused deposition modelling (FDM) technology, the field is still poorly explored. A design of experiment study was conducted to understand the complete set of process parameters of a custom developed FDM 3D printer and their influence on tablet disintegration time. Nine settings in the Simplify 3D printing process design software were evaluated with further experimental investigation conducted on the influence of infill percentage, infill pattern, nozzle diameter, and layer height. The percentage of infill was identified as the most impactful parameter, as increasing it parabolically affected the increase of disintegration time. Furthermore, a larger nozzle diameter prolonged tablet disintegration, since thicker extruded strands are generated through wider nozzles during the printing process. Three infill patterns were selected for in-depth analysis, demonstrating the clear importance of the geometry of the internal structure to resist mechanical stress during the disintegration test. Lastly, layer height did not influence the disintegration time. A statistical model with accurate fit ($R^2$ = 0.928) and predictability ($Q^2$ = 0.847) was created. In addition, only the infill pattern and layer height influenced both the uniformity of mass and uniformity of the disintegration time, which demonstrates the robustness of the printing process.

• Jezik: Angleški jezik
• Ključne besede: 3D printed tablets, disintegration time, fused depo-sition modelling, design of experiments, printing parameters, uniformity of mass
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: Str. 405-422
• Številčenje: Vol. 73, no. 3
• PID: 20.500.12556/RUL-151579
• UDK: 615.45
• ISSN pri članku: 1330-0075
• DOI: 10.2478/acph-2023-0026
• COBISS.SI-ID: 167452419
• Datum objave v RUL: 10.10.2023

Gradivo je del revije

• Naslov: Acta pharmaceutica
• Skrajšan naslov: Acta pharm.
• Založnik: Hrvatsko farmaceutsko društvo
• ISSN: 1330-0075
• COBISS.SI-ID: 13497349

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: 3D tiskane tablete, razpadni čas, modeliranje taljenega nanosa, zasnova eksperimentov, parametri tiskanja, enakomernost mase

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0189
• Naslov: Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih