Toll-like receptors (TLRs) are the most studied receptors in the group of molecular pattern-recognition receptors (PRRs). TLRs include TLR10, that is important for recognition of pathogens and regulation of the immune response activation. In my thesis we compared the DNA sequences of TLR10 from different mammalian species and compared the nucleotide sequences of the core promoters of human TLR1, TLR2, TLR6 and TLR10. We also compared the core promoter sequences of human TLR10 with those of different mammalian species. Finally, we searched for transcription factor binding sites and compared their conservation in the TLR10 core promoter in different mammalian species. The results show a high degree of sequence conservation in the promoter regions and binding sites of human TLR10 transcription factors in different mammalian species.
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