2-Isobutyl-3-methoxypyrazine (IBMP) was prepared from N-Boc-L-leucine using two different synthesis pathways. Following the first synthesis pathway, an amide was synthesized with 2-aminoethanol and then the alcohol part was oxidized to an aldehyde. Afterwards, the aldehyde was cyclized under acidic conditions to pyrazinone, which was chlorinated and converted to the final methoxypyrazine by nucleophilic aromatic substitution. Using another synthesis pathway, L-leucinamide was prepared from N-Boc-L-leucine. This was followed by cyclization with glyoxal to pyrazinone. Pyrazinone was than alkylated with methyl iodide or, as in the first synthesis pathway, chlorinated and converted into methoxypyrazine by nucleophilic aromatic substitution.
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