Introduction: Epidermolysis bullosa (lat. epidermolysis bullosa, EB) is a group of inherited genetic disorders associated with skin fragility. Minimal mechanical trauma or spontaneous skin fragility can lead to blistering, erosions and scarring. The disease is caused by mutations in different genes that code for different proteins that connect the layers of skin cells. The disease is classified into four basic types: EB simplex, junctional EB, dystrophic EB and Kindler syndrome. Purpose: The aim of this thesis is to present the medical management and care of the newborn with EB, and we have therefore delved into this area, as it has a significant impact on the quality of life later in childhood and adulthood. It is important that parents of children with disabilities and health professionals provided with appropriate and accessible information. The thesis will also be aimed for a wider community of people. Methods: In this thesis we used a descriptive method with a systematic literature review. The timeframe used for the search was 2010 to 2021. The data collection was carried out by reviewing and critically selecting the professional and scientific literature in Slovenian and English. Results: Wound healing in newborns is different that in children or adults so that is why it requires special care. Skin is physiologically and developmentally different, so the care plan needs to be individualised according to the age, signs of disease, complications and the patient's priorities. Patient wounds are usually cleaned and treated once a day or as needed. The treatment is carried out on a soft surface using a rolling and lifting technique. Any pressure on the skin, for example; rubbing with a towel or nappy can provoke the formation of a new blister. Particularly sensitive are hands, elbows, wrists, feet and knees. We are consistently over-penetrating blisters, because otherwise they spread. The nutritional needs of newborns with EB are higher than those of healthy children, due to rapid skin repair and the need for increased calorie intake. Discussion and conclusion: The basic principles of care for all EB patients are to prevent blistering and to prevent secondary infections. Due to the rarity of the disease, most families of newborns find themselves with little or zero experience when faced with EB disease. Regardless of the subtype, all EB patients have in common blistering of the skin, which result in persistent wounds. Specific aspects of the host, the healing process and the wound need to be taken into account in patients with this debilitating disease to facilitate the healing process.
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