How early maternal deprivation changes the brain and behavior?

Čater, Maša (avtor), Majdič, Gregor (avtor)

Early life stress can adversely influence brain development and reprogram brain function and consequently behavior in adult life. Adequate maternal care in early childhood is therefore particularly important for the normal brain development, and adverse early life experiences can lead to altered emotional, behavioral, and neuroendocrine stress responses in the adulthood. As a form of neonatal stress, maternal deprivation/separation is often used in behavioral studies to examine the effects of early life stress and for modeling the development of certain psychiatric disorders and brain pathologies in animal models. The temporary loss of maternal care during the critical postpartum periods remodels the offspring's brain and provokes long-term effects on learning and cognition, the development of mental disorders, aggression, and an increased tendency for the drug abuse. Early life stress through maternal deprivation affects neuroendocrine responses to stress in adolescence and adulthood by dysregulating the hypothalamic–pituitary–adrenal axis and permanently disrupts stress resilience. In this review, we focused on how improper maternal care during early postnatal life affects brain development resulting in modified behavior later in life.

• Jezik: Angleški jezik
• Ključne besede: behavior, brain, development, maternal deprivation, programming, stress
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: VF - Veterinarska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Datum objave: 01.01.2022
• Leto izida: 2022
• Št. strani: Str. 2058-2075
• Številčenje: Vol. 55, no. 9/10
• PID: 20.500.12556/RUL-140821
• UDK: 612
• ISSN pri članku: 1460-9568
• DOI: 10.1111/ejn.15238
• COBISS.SI-ID: 64141571
• Datum objave v RUL: 19.09.2022

Gradivo je del revije

• Naslov: European journal of neuroscience
• Skrajšan naslov: EJN, Eur. j. neurosci.
• Založnik: Wiley, Federation of European Neuroscience Societies
• ISSN: 1460-9568
• COBISS.SI-ID: 517706521

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 19.09.2022

Projekti

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: EU, MIZŠ: C3330-17-529030