In recent years, there has been an intensive development of C−H activation reactions in the field of organic synthesis, as they do not require pre-functionalization, because direct cleavage of unreactive C−H bond takes place, which reduces the number of reaction steps and prevents the formation of a large number of side products. Reactions mostly use noble 4d and 5d transition metals for catalysts because of their good catalytic properties. Among C−H activation reactions, attention is increasingly directed towards more environmentally friendly reactions, catalyzed by 3d transition metals. Compared to precious metals, these are less toxic, easier to access and cheaper. In my thesis, I will first summarize the traditional cross-coupling reactions in the introduction and give a general presentation of C−H activation. Then, I will present each 3d transition metal separately and describe how it catalyzes one C−C bond formation reaction and one C−Het bond formation reaction.
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