Interactome of PTH-Regulated miRNAs and their predicted target genes for Investigating the epigenetic effects of PTH (1–34) in bone metabolism

Vrščaj, Lucija Ana (avtor), Marc, Janja (avtor), Ostanek, Barbara (avtor)

Osteoporosis is a metabolic bone disease that mostly affects the elderly. A lot of drugs are available, mostly with an antiresorptive effect but just a few with an osteoanabolic effect, meaning they promote bone building. PTH (1-34) or teriparatide is an osteoanabolic drug, but its efficacy varies between individuals. We performed a literature review and extracted a dataset of 62 microRNAs (miRNAs) from 10 different studies; predicted miRNA target interactions (MTIs) were obtained with the help of four software tools: DIANA, miRWalk, miRDB and TargetScan. With the construction of an interactome of PTH-regulated miRNAs and their predicted target genes, we elucidated miR-146a-5p, miR-551b-5p, miR-205-3p, miR-33a-3p, miR-338-5p as miRNAs with the most interactions and miR-410-3p as the miRNA targeting bone-related pathways with the highest significance. These miRNAs could help in further understanding the mechanism of action of PTH on bone metabolism and osteoporosis. They also have the potential for novel network-based biomarkers for osteoporosis treatment efficacy and safety and as new therapeutic targets.

• Jezik: Angleški jezik
• Ključne besede: osteoporosis, osteoporosis treatment, microRNA, parathyroid hormone, teriparatide, network, Cytoscape, biological pathway, gene enrichment biomarker
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Datum objave: 13.08.2022
• Leto izida: 2022
• Št. strani: Str. 1-15
• Številčenje: Vol. 13, iss. 8, art. 1443
• PID: 20.500.12556/RUL-138758
• UDK: 616.71-007.234:616-085
• ISSN pri članku: 2073-4425
• DOI: 10.3390/genes13081443
• COBISS.SI-ID: 118226947
• Datum objave v RUL: 16.08.2022

Gradivo je del revije

• Naslov: Genes
• Skrajšan naslov: Genes
• Založnik: Multidisciplinary Digital Publishing Institute (MDPI)
• ISSN: 2073-4425
• COBISS.SI-ID: 523100185

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 16.08.2022

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: zdravljenje osteoporoze, mikroRNA, paratiroidni hormon, teriparatid, omrežje, biomarker za obogatitev genov, biološka pot

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0298
• Naslov: Geni, hormonske in osebnostne spremembe pri metabolnih motnjah

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: J3-1759
• Naslov: Celostna karakterizacija zadetkov analiz GWAS - pot do novih terapevtskih tarč za anabolno zdravljenje osteoporoze(GWASforAna)