Progression of coronary calcium burden and carotid stiffness in patients with essential thrombocythemia associated with JAK2 V617F mutation

Anžič Drofenik, Ajda (avtor), Vrtovec, Matjaž (avtor), Božič, Mojca (avtor), Sever, Matjaž (avtor), Preložnik Zupan, Irena (avtor), Kejžar, Nataša (avtor), Blinc, Aleš (avtor)

Background and aims: Patients with myeloproliferative neoplasms often succumb to cardiovascular events, but little is known on the early stages of their vascular disease. We studied how patients with JAK2 V617F positive essential thrombocythemia (ET) without overt atherosclerotic disease differed from control subjects in the progression of carotid artery stiffness and preclinical atherosclerosis. Methods: Thirty-six patients with JAK2 V617F positive ET and 38 age-, gender- and Framingham coronary heart disease (CHD) -matched control subjects were examined twice within 4 years. Clinical and laboratory testing, echo-tracking ultrasound of carotid arteries, coronary calcium measurement and digital plethysmography were performed (ClinTrials.gov NCT03828422). Results: Coronary calcium correlated with the Framingham CHD risk score at the first examination in the control group (r$_s$ = 0.410), but not among the ET patients (r$_s$ = 0.116). Both groups progressed in coronary calcium, but the outliers were more prominent among ET patients. Carotid artery stiffness increased with time in the ET patients much more than in the control group: the increase in β-index 1.95 (SD 2.18) vs. 0.22 (SD 1.99), p < 0.001, and the increase in carotid pulse wave velocity 0.72 (SD 0.92) vs. 0.08 (SD 0.72) m/s, p = 0.001. There was no correlation between carotid stiffness and Framingham CHD risk in either group. Digital endothelial function did not change. Conclusion: Carotid artery stiffness progressed faster in patients with JAK2 V617F positive ET than in control subjects. Coronary calcium correlated with the Framingham CHD risk only in control subjects. This indicates that JAK2 V617F positive ET acted as a non-classical risk factor for vascular disease.

• Jezik: Angleški jezik
• Ključne besede: essential thrombocythemia, JAK2 V617F mutation, arterial stiffness, coronary calcium, cardiovascular risk
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: Str. 25-31
• Številčenje: Vol. 296
• PID: 20.500.12556/RUL-137781
• UDK: 616.1
• ISSN pri članku: 0021-9150
• DOI: 10.1016/j.atherosclerosis.2020.01.001
• COBISS.SI-ID: 6959276
• Datum objave v RUL: 30.06.2022

Gradivo je del revije

• Naslov: Atherosclerosis
• Skrajšan naslov: Atherosclerosis
• Založnik: Elsevier
• ISSN: 0021-9150
• COBISS.SI-ID: 25033216

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.