Oral glucose load and human cutaneous microcirculation : an insight into flowmotion assessed by wavelet transform

Silva, Henrique (avtor), Šorli, Jernej (avtor), Lenasi, Helena (avtor)

Microcirculation in vivo has been assessed using non-invasive technologies such as laser Doppler flowmetry (LDF). In contrast to chronic hyperglycemia, known to induce microvascular dysfunction, the effects of short-term elevations in blood glucose on microcirculation are controversial. We aimed to assess the impact of an oral glucose load (OGL) on the cutaneous microcirculation of healthy subjects, quantified by LDF and coupled with wavelet transform (WT) as an interpretation tool. On two separate occasions, sixteen subjects drank either a glucose solution (75 g in 250 mL water) or water (equal volume). LDF signals were obtained in two anatomical sites (forearm and finger pulp) before and after each load (pre-load and post-load, respectively), in resting conditions and during post-occlusive reactive hyperemia (PORH). The WT allowed decomposition of the LDF signals into their spectral components (cardiac, respiratory, myogenic, sympathetic, endothelial NO-dependent). The OGL blunted the PORH response in the forearm, which was not observed with the water load. Significant differences were found for the cardiac and sympathetic components in the glucose and water groups between the pre-load and post-load periods. These results suggest that an OGL induces a short-term subtle microvascular impairment, probably involving a modulation of the sympathetic nervous system.

• Jezik: Angleški jezik
• Ključne besede: diabetes mellitus, microcirculation, laser Doppler flowmetry, wavelet transform, oral glucose load, flowmotion, post-occlusive reactive hyperemia
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 17 str.
• Številčenje: Vol. 10, iss. 10, art. 953
• PID: 20.500.12556/RUL-136335
• UDK: 612
• ISSN pri članku: 2079-7737
• DOI: 10.3390/biology10100953
• COBISS.SI-ID: 83675651
• Datum objave v RUL: 25.04.2022

Gradivo je del revije

• Naslov: Biology
• Skrajšan naslov: Biology
• Založnik: MDPI
• ISSN: 2079-7737
• COBISS.SI-ID: 523004441

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.10.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: sladkorna bolezen, mikrocirkulacija, laserska Dopplerjeva flowmetrija

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0019
• Naslov: Aplikativna in bazična fiziologija in patofiziologija v medicini