Estrogens and the Schrödinger's cat in the ovarian tumor microenvironment

Gjorgoska, Marija (avtor), Lanišnik-Rižner, Tea (avtor)

Ovarian cancer is a heterogeneous disease affecting the aging ovary, in concert with a complex network of cells and signals, together representing the ovarian tumor microenvironment. As in the “Schrödinger’s cat” thought experiment, the context-dependent constituents of the—by the time of diagnosis—well-established tumor microenvironment may display a tumor-protective and -destructive role. Systemic and locally synthesized estrogens contribute to the formation of a pro-tumoral microenvironment that enables the sustained tumor growth, invasion and metastasis. Here we focus on the estrogen biosynthetic and metabolic pathways in ovarian cancer and elaborate their actions on phenotypically plastic, estrogen-responsive, aging immune cells of the tumor microenvironment, altogether highlighting the multicomponent-connectedness and complexity of cancer, and contributing to a broader understanding of the ovarian cancer biology.

• Jezik: Angleški jezik
• Ključne besede: ovarian cancer, estrogens, immunosuppressive microenvironment, plasticity
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 17 str.
• Številčenje: Vol. 13, iss. 19, art. 5011
• PID: 20.500.12556/RUL-136270
• UDK: 616-006
• ISSN pri članku: 2072-6694
• DOI: 10.3390/cancers13195011
• COBISS.SI-ID: 79662851
• Datum objave v RUL: 21.04.2022

Gradivo je del revije

• Naslov: Cancers
• Skrajšan naslov: Cancers
• Založnik: MDPI
• ISSN: 2072-6694
• COBISS.SI-ID: 517914137

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 06.10.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: rak jajčnikov, estrogeni, imunosupresivno mikrookolje

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: J3-2535
• Naslov: Vloga androgenov pri hormonsko odvisnih boleznih: pomen za diagnostiko in zdravljenje