Comparison of solution chemical properties and biological activity of ruthenium complexes of selected ß-diketone, 8-hydroxyquinoline and pyrithione ligands

Pivarcsik, Tamás (avtor), Tóth, Gábor (avtor), Szemerédi, Nikoletta (avtor), Bogdanov, Anita (avtor), Spengler, Gabriella (avtor), Kljun, Jakob (avtor), Kladnik, Jerneja (avtor), Turel, Iztok (avtor), Enyedy, Éva A. (avtor)

In this work, the various biological activities of eight organoruthenium(II) complexes were evaluated to reveal correlations with their stability and reactivity in aqueous media. Complexes with general formula [Ru(η$^6$-p-cymene)(X,Y)(Z)] were prepared, where (X,Y) represents either an O,Oligand (β-diketone), N,O-ligand (8-hydroxyquinoline) or O,S-pyrithione-type ligands (pyrithione = 1-hydroxypyridine-2(1H)-thione) with Cl$^−$ or 1,3,5-triaza-7-phosphaadamantane (PTA) as a co-ligand (Z). The tested complexes inhibit the chlamydial growth on HeLa cells, and one of the complexes inhibits the growth of the human herpes simplex virus-2. The chlorido complexes with N,O- and O,S-ligands displayed strong antibacterial activity on Gram-positive strains including the resistant S. aureus (MRSA) and were cytotoxic in adenocarcinoma cell lines. Effect of the structural variation on the biological properties and solution stability was clearly revealed. The decreased bioactivity of the β-diketone complexes can be related to their lower stability in solution. In contrast, the O,Spyrithione-type complexes are highly stable in solution and the complexation prevents the oxidation of the O,S-ligands. Comparing the binding of PTA and the chlorido co-ligands, it can be concluded that PTA is generally more strongly coordinated to ruthenium, which at the same time decreased the reactivity of complexes with human serum albumin or 1-methylimidazole as well as diminished their bioactivity.

• Jezik: Angleški jezik
• Ključne besede: MTT assay, UV-vis, solution stability, MRSA, albumin binding, ligand effect
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 24 str.
• Številčenje: Vol. 14, iss. 6, art. 518
• PID: 20.500.12556/RUL-135430
• UDK: 546.96:547.8
• ISSN pri članku: 1424-8247
• DOI: 10.3390/ph14060518
• COBISS.SI-ID: 65179139
• Datum objave v RUL: 14.03.2022

Gradivo je del revije

• Naslov: Pharmaceuticals
• Skrajšan naslov: Pharmaceuticals
• Založnik: MDPI
• ISSN: 1424-8247
• COBISS.SI-ID: 517582617

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.06.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: rutenij, organorutenijevi kompleksi, ligandi, kemijske lastnosti, biološka aktivnost