Effect of statin use on the clinical manifestations, laboratory test results and outcome of Lyme neuroborreliosis

Ogrinc, Katarina (avtor), Kastrin, Andrej (avtor), Lotrič-Furlan, Stanka (avtor), Bogovič, Petra (avtor), Rojko, Tereza (avtor), Cerar Kišek, Tjaša (avtor), Ružić-Sabljić, Eva (avtor), Wormser, Gary P. (avtor), Strle, Franc (avtor)

Statins have anti-inflammatory and potentially antimicrobial activity, but whether they have a beneficial effect on the course of infectious diseases is controversial. In this study, we assessed the impact of pre-existing statin use on the course and outcome of Lyme neuroborreliosis manifested as meningoradiculitis (Bannwarth’s syndrome). One hundred and twenty three consecutive patients with Bannwarth’s syndrome, of whom 18 (14.6%) were being treated with statins, were included in the study. To assess the influence of statin use on the course and outcome of the disease, univariate and multivariable analyses were performed. No statistically significant association was found between statin pre-treatment and the clinical manifestations, laboratory test results, and outcome of Bannwarth’s syndrome. In conclusion, pre-existing use of statins did not significantly impact either the clinical presentation or the outcome of Bannwarth’s syndrome.

• Jezik: Angleški jezik
• Ključne besede: Lyme neuroborreliosis, Bannwarth's syndrome, statin, course, outcome
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 11 str.
• Številčenje: Vol. 9, iss. 9, art. 2995
• PID: 20.500.12556/RUL-134358
• UDK: 616.9
• ISSN pri članku: 2077-0383
• DOI: 10.3390/jcm9092995
• COBISS.SI-ID: 29554435
• Datum objave v RUL: 10.01.2022

Gradivo je del revije

• Naslov: Journal of clinical medicine
• Skrajšan naslov: J. clin. med.
• Založnik: MDPI
• ISSN: 2077-0383
• COBISS.SI-ID: 5405759

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 16.09.2020

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0296
• Naslov: Bolezni in povzročitelji, ki jih v Sloveniji prenašajo členonožci