Copper(II) complexes with mixed heterocycle ligands as promising antibacterial and antitumor species

Rostas, Arpad Mihai (avtor), Badea, Mihaela (avtor), Ruţǎ, Lavinia L. (avtor), Farcaşanu, Ileana C. (avtor), Maxim, Cǎtǎlin (avtor), Chifiriuc, Mariana Carmen (avtor), Popa, Marcela (avtor), Luca, Mirela (avtor), Čelan Korošin, Nataša (avtor), Cerc Korošec, Romana (avtor), Bacalum, Mihaela (avtor), Raileanu, Mina (avtor), Olar, Rodica (avtor)

Complexes with mixed ligands [Cu(N-N)$_2$(pmtp)](ClO$_4$)$_2$ ((1) N-N: 2,2′-bipyridine; (2) L: 1,10-phenanthroline and pmpt: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesized and structurally and biologically characterized. Compound (1) crystallizes into space group Pa and (2) in P-1. Both complexes display an intermediate stereochemistry between the two five-coordinated ones. The biological tests indicated that the two compounds exhibited superoxide scavenging capacity, intercalative DNA properties, and metallonuclease activity. Tests on various cell systems indicated that the two complexes neither interfere with the proliferation of Saccharomyces cerevisiae or BJ healthy skin cells, nor cause hemolysis in the active concentration range. Nevertheless, the compounds showed antibacterial potential, with complex (2) being significantly more active than complex (1) against all tested bacterial strains, both in planktonic and biofilm growth state. Both complexes exhibited a very good activity against B16 melanoma cells, with a higher specificity being displayed by compound (1). Taken together, the results indicate that complexes (1) and (2) have specific biological relevance, with potential for the development of antitumor or antimicrobial drugs.

• Jezik: Angleški jezik
• Ključne besede: copper(II) complex, 1, 2, 4-triazolo[1, 5-a]pyrimidine, cytotoxicity, biofilm, metallonuclease activity, DNA intercalation
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FKKT - Fakulteta za kemijo in kemijsko tehnologijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 22 str.
• Številčenje: Vol. 25, iss. 17, art. 3777
• PID: 20.500.12556/RUL-134318
• UDK: 546.56:547.853
• ISSN pri članku: 1420-3049
• DOI: 10.3390/molecules25173777
• COBISS.SI-ID: 26455043
• Datum objave v RUL: 05.01.2022

Gradivo je del revije

• Naslov: Molecules
• Skrajšan naslov: Molecules
• Založnik: MDPI
• ISSN: 1420-3049
• COBISS.SI-ID: 18462981

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.09.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: baker, bakrovi kompleksi, 1, 2, 4-triazolo[1, 5-a]pirimidin, citotoksičnost

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0134
• Naslov: Kemija za trajnostni razvoj