Numerous studies indicate that micro- and meso-flow systems are excellent tools for modern production of fine chemicals and active pharmaceutical ingredients due to their properties, especially efficient heat and mass transfer. By using them, we can improve the yields and selectivity of a process while reducing the consumption of energy, solvents and reagents and, with the help of automation, human labor. For the above reasons, the implementation of micro- and meso-flow technologies for the production of active pharmaceutical ingredients is one of the main routes for the transition to sustainable production.
The master thesis deals with the transfer of the synthesis of the intermediate of the selected active pharmaceutical ingredient from batch to the micro- and meso-flow systems. For this purpose, the properties of the raw materials used for the synthesis were studied and basic data on the batch operation of the process were obtained. The synthesis was then carried out in microreactors with different flow patterns, mixing modes and dosages of reactants and finally also in a meso-flow reactor. Based on the results obtained, it was concluded that by-products formed during the reaction negatively affect the process and should be removed in situ. It was also found that the process is primarily limited by reaction kinetics rather than heat and mass transfer. Efficient heat transfer in microflow systems also allows faster dosing of reagents that cause exothermic reactions.
|
