Inflammatory immune responses in the pathogenesis of tick-borne encephalitis

Bogovič, Petra (avtor), Lusa, Lara (avtor), Korva, Miša (avtor), Marušić, Miša (avtor), Resman Rus, Katarina (avtor), Lotrič-Furlan, Stanka (avtor), Avšič-Županc, Tatjana (avtor), Strle, Klemen (avtor), Strle, Franc (avtor)

Clinical manifestations of tick-borne encephalitis (TBE) are thought to result from the host immune responses to infection, but knowledge of such responses is incomplete. We performed a detailed clinical evaluation and characterization of innate and adaptive inflammatory immune responses in matched serum and cerebrospinal fluid (CSF) samples from 81 adult patients with TBE. Immune responses were then correlated with laboratory and clinical findings. The inflammatory immune responses were generally site-specific. Cytokines and chemokines associated with innate and Th1 adaptive immune responses were significantly higher in CSF, while mediators associated with Th17 and B-cell responses were generally higher in serum. Furthermore, mediators associated with innate and Th1 adaptive immune responses were positively associated with disease severity, whereas Th17 and B cell immune responses were not. During the meningoencephalitic phase of TBE, innate and Th1 adaptive inflammatory mediators were highly concentrated in CSF, the site of the disease. The consequence of this robust immune response was more severe acute illness. In contrast, inflammatory mediators associated with B cell and particularly Th17 responses were concentrated in serum. These findings provide new insights into the immunopathogenesis of TBE and implicate innate and Th1 adaptive responses in severity and clinical presentation of acute illness.

• Jezik: Angleški jezik
• Ključne besede: tick-borne encephalitis, inflammatory mediators, innate immunity, adaptive immunity, cytokines, chemokines, cerebrospinal fluid, severity of illness
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2019
• Št. strani: 16 str.
• Številčenje: Vol. 8, iss. 5, art. 731
• PID: 20.500.12556/RUL-132320
• UDK: 616.9
• ISSN pri članku: 2077-0383
• DOI: 10.3390/jcm8050731
• COBISS.SI-ID: 6109612
• Datum objave v RUL: 21.10.2021

Gradivo je del revije

• Naslov: Journal of clinical medicine
• Skrajšan naslov: J. clin. med.
• Založnik: MDPI
• ISSN: 2077-0383
• COBISS.SI-ID: 5405759

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 22.05.2019

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0296
• Naslov: Bolezni in povzročitelji, ki jih v Sloveniji prenašajo členonožci

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: MGH-ECOR