Oleanolic acid alters multiple cell signaling pathways : implication in cancer prevention and therapy

Žiberna, Lovro (avtor), Šamec, Dunja (avtor), Mocan, Andrei (avtor), Nabavi, Seyed F. (avtor), Bishayee, Anupam (avtor), Farooqi, Ammad Ahmad (avtor), Sureda, Antoni (avtor), Nabavi, Seyed M. (avtor)

Nowadays, much attention has been paid to diet and dietary supplements as a cost-effective therapeutic strategy for prevention and treatment of a myriad of chronic and degenerative diseases. Rapidly accumulating scientific evidence achieved through high-throughput technologies has greatly expanded the understanding about the multifaceted nature of cancer. Increasingly, it is being realized that deregulation of spatio-temporally controlled intracellular signaling cascades plays a contributory role in the onset and progression of cancer. Therefore, targeting regulators of oncogenic signaling cascades is essential to prevent and treat cancer. A plethora of preclinical and epidemiological evidences showed promising role of phytochemicals against several types of cancer. Oleanolic acid, a common pentacyclic triterpenoid, is mainly found in olive oil, as well as several plant species. It is a potent inhibitor of cellular inflammatory process and a well-known inducer of phase 2 xenobiotic biotransformation enzymes. Main molecular mechanisms underlying anticancer effects of oleanolic acid are mediated by caspases, 5′ adenosine monophosphate-activated protein kinase, extracellular signal-regulated kinase 1/2, matrix metalloproteinases, pro-apoptotic Bax and bid, phosphatidylinositide 3-kinase/Akt1/mechanistic target of rapamycin, reactive oxygen species/apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase, nuclear factor-κB, cluster of differentiation 1, CKD4, s6k, signal transducer and activator of transcription 3, as well as aforementioned signaling pathways. In this work, we critically review the scientific literature on the molecular targets of oleanolic acid implicated in the prevention and treatment of several types of cancer. We also discuss chemical aspects, natural sources, bioavailability, and safety of this bioactive phytochemical.

• Jezik: Angleški jezik
• Ključne besede: healthy diet, oleanolic acid, anticancer effect, olive, signaling pathways
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2017
• Št. strani: 16 str.
• Številčenje: Vol. 18, iss. 3, art. 643
• PID: 20.500.12556/RUL-131184
• UDK: 613.2
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms18030643
• COBISS.SI-ID: 33140953
• Datum objave v RUL: 23.09.2021

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 16.03.2017

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: zdrava prehrana, oleinska kislina, učinek proti raku

Projekti

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: Spanish Ministry of Health, Social Services and Equality
• Številka projekta: CIBEROBN—CB12/03/30038