The pore-forming action of polyenes : from model membranes to living organisms

Kristanc, Luka (avtor), Božič, Bojan (avtor), Zemljič Jokhadar, Špela (avtor), Sollner Dolenc, Marija (avtor), Gomišček, Gregor (avtor)

The incidence of resistant fungal pathogens has been increasing, especially in immuno-compromised people. As such, considerable research has been focused on discovering anti-fungal agents with new mechanisms of action and on optimizing the use of existing agents. In this context, interest in the polyene group of anti-fungals has recently been renewed, since they are known to be effective against a broad spectrum of fungal pathogens that only rarely develop a resistance to them. In the past 10 years considerable efforts have been made to improve their efficacy and, simultaneously, to reduce their toxicity. Knowledge about the basic mechanisms of their action will be of crucial importance to further optimizing their use. The mechanisms of polyene action at the membrane level are reviewed here, focusing primarily on their pore-forming activity and on the resulting osmotic responses of artificial lipid vesicles and different eukaryotic cells.

• Jezik: Angleški jezik
• Ključne besede: polyenes, sterols, pore-forming, tension pore, osmotic stress
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta ; FFA - Fakulteta za farmacijo ; ZF - Zdravstvena fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2019
• Št. strani: Str. 418-430
• Številčenje: Vol. 1861, iss. 2
• PID: 20.500.12556/RUL-128754
• UDK: 579+616
• ISSN pri članku: 0005-2736
• DOI: 10.1016/j.bbamem.2018.11.006
• COBISS.SI-ID: 4634737
• Datum objave v RUL: 27.07.2021

Gradivo je del revije

• Naslov: Biochimica et biophysica acta. Biomembranes
• Skrajšan naslov: Biochim. biophys. acta, Biomembr.
• Založnik: Elsevier
• ISSN: 0005-2736
• COBISS.SI-ID: 4077101

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
• Začetek licenciranja: 01.02.2019

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: polieni, steroli, tvorjenje por, tenzijska pora, osmotski stres

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0055
• Naslov: Biofizika polimerov, membran, gelov, koloidov in celic