Introduction: Multiple sclerosis is a chronic autoimmune inflammatory disease that affects the central nervous system. It most often occurs at young age - between 20 and 40 years of age. During the process, the nerve fiber sheaths fail mainly due to damage and loss of myelin. Only this causes a slowing down or even interruption of the conduction of nerve stimuli (impulses) along the nerve fibers, which in turn causes certain symptoms. The most common symptoms are fatigue, balance problems, tingling, double vision and pain in the arms and legs. This prevents people with multiple sclerosis engage and participate in various occupations and reduce their quality of life. Purpose: The aim of the research was to investigate how the diagnosis changed the life of people with multiple sclerosis, what areas of activities were identified as being difficult, how these problems exposed and in what way they engage in daily activities. Furthermore we wanted to determinate the level of help received from the enviroment and the way people with multiple sclerosis were accepting and dealing with the disease. Methods: A qualitative research was conducted, for which data were obtained through semi-structured interviews. Four people with multiple sclerosis were included in the study. Interviews were audio-recorded and transcripts were analyzed by qualitative content analysis. Results: The diagnosis of multiple sclerosis is life-changing for individuals. Due to the symptoms that the diagnosis brings, they find it increasingly difficult to engage in daily activities, and as a result, their quality of life is reduced. The disease has consequences in all aspects: leisure, self-care and productivity, and it also has a great impact on the social network. People with multiple sclerosis often give up some occupations due to difficulties in performance or preform them in an adapted way. They use different aids, implement rest or use the help of others. Discussion and conclusion: People with multiple sclerosis face many challenges on a daily basis due to the disease. The difficulties are easier to overcome with the help of their family, relatives and friends. People are forced to make various adjustments, and some even give up certain activities. The disease also affects people in the mental health, which often makes them feel useless and insecure, but they still accept the disease and try to learn to live with it. Due to lack of knowledge about the personal experience of the disease, more extensive research should be done on this topic. This would give a better understanding into their experience, better understand them and make it easier to design occupational therapy treatments.
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