Due to their varied and complex biological activities, oxindole and its spirocyclic derivatives represent an important group of molecules for the synthesis of potential pharmaceutically active compounds. Chiral active compounds require specific stereochemistry, which is achieved through the use of various (organo)catalysts. In the introduction of the diploma thesis, the history of organocatalysis and the mode of action of different organocatalysts is described, followed by the description of oxindole and its derivatives, their application, and the different mechanisms/routes of their synthesis. A typical procedure for the preparation of 3-isothiocyantooxindole from isatin is described. In the fourth chapter, a survey of known organocatalyzed transformations of isothiocyanates based on oxindole is presented. Optimal reaction conditions, catalysts, yields, and stereoselectivities are included. Closing remarks include a short summary of organocatalyzed transformations and applied catalysts.
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